Weight uniformity in tablet manufacturing - the critical role in tablet efficacy

October 22, 2024

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The article discusses the critical importance of tablet weight uniformity in the tablet manufacturing process, emphasizing its role in ensuring that each tablet consistently delivers the intended dosage of key ingredients. It highlights the challenges and factors that can affect weight uniformity, including:

- Physical characteristics of formulation components: Variability in particle size, density, and hygroscopicity (moisture absorption) can disrupt powder flow and compression.

- Mechanical equipment interaction: Inconsistencies in tablet press settings, tooling wear, and die fill variability impact weight accuracy.

- Processing practices: Issues with mixing, granulation, and lubrication affect uniformity.

To overcome these challenges, the author suggests strategies such as careful formulation development, equipment maintenance, process optimization, and continuous quality monitoring. By addressing these factors, manufacturers can ensure consistent tablet weight and product efficacy. The series, guided by insights from Jesus Lopez of Techceuticals, will continue to explore key aspects of tablet manufacturing.