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    Impact of solid content on the bulk properties of lyophilized powders

    Impact of solid content on the bulk properties of lyophilized powders

    Papers - 10/02/2025 - by Zijian Wang, Sichen Song, Hongwei Zhang, Xiaohong Liu, Ronald A. Siegel, Changquan Calvin Sun, Chenguang Wang
    Interest in the oral delivery of biologics, often formulated via lyophilization, is growing rapidly. Lyophilization typically uses solutions with low solid content to optimize mass transfer and reduce drying time. …
    Image effect of glidant on tabletting behavior

    The effect of glidant on the tabletting behavior of common pharmaceutical excipients

    Newsfeeds - 09/08/2024 -
    The article on Pharma Excipients discusses the impact of glidants on the tabletting process in pharmaceutical manufacturing. Glidants are substances added to improve the flow properties of powders during tablet …
    assorted single-layer tablets on grey background

    Mimicking dry granulation on the STYL'One Evo to improve flowability

    Bulletins - 16/04/2024 - by Sixtine Caquant, Adrien Pelloux
    Dry granulation is a commonly used process in the pharmaceutical industry. It provides several key advantages, including precise particle size control, improved flowability of powders, versatility in processing materials, increased …
    Impact of dry coating lactose as a brittle excipient on multi-component blend processability

    Impact of dry coating lactose as a brittle excipient on multi-component blend processability

    Papers - 20/02/2024 - by Zhixing Lin, Bian Cabello, Rajesh N. Davé
    Prior research has shown the advantages of applying dry coating to finely graded microcrystalline cellulose (MCC) to facilitate direct compression (DC), a preferred method in tablet manufacturing. This process enhances …
    Rotary tablet press - KORSCH

    The critical role of product die filling

    White Papers - 01/02/2024 - by Friederike Guetter
    Product flow and consistent die filling are essential factors for successful tableting. For successful tablet production, many process steps must be harmonized with each other.
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    Use of Polyvinyl Alcohol as an effective binder in continuous Twin-Screw Granulation

    Papers - 01/02/2024 - by Gudrun Birk, Anja-Nadine Knüttel, Almut von der Brelie
    Granulation of powder blends is a frequently employed method in pharmaceutical formulations when there are issues with flowability, compactability, or uniformity in terms of the active pharmaceutical ingredient (API) content. …
    Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

    Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

    Papers - 08/12/2023 - by Natalia Veronica, Yi Ying Loh, Lydia Xiu Ying Loh, Paul Wan Sia Heng, Celine Valeria Liew
    Improving the Manufacturability of Cohesive and Poorly Compactable API for Direct Compression of Mini-tablets at High Drug Loading via Particle Engineering

    Improving the manufacturability of cohesive and poorly compactable API for direct compression of mini-tablets at high drug loading via particle engineering

    Papers - 01/11/2022 - by Liang Chen, Yiqing Lin, Erwin Irdam, Nicole Madden, Frederick Osei-Yeboah
    The aim is to employ a particle engineering approach to enhance the manufacturability of a cohesive and challenging-to-compact active pharmaceutical ingredient (API) with a high drug loading, specifically for the …
    Charge reduction assisted production of diminutive fluid bed granules for high drug load minitablets

    Charge reduction assisted production of diminutive fluid bed granules for high drug load minitablets

    Papers - 25/07/2022 - by Shang Jun Loo, Paul Wan Sia Heng, Lai Wah Chan
    Micronized drug powders are often impractical for use as tableting feed to create minitablets due to their cohesiveness and poor flow properties. The addition of fumed silica (fSi) within an …
    MEDELPHARM Science Lab powder angle of repose

    Assess the impact of your granulation process parameters with the STYL'One Evo

    Bulletins - 01/03/2022 - by Sixtine Caquant, Adrien Pelloux
    Powder granulation is commonly used in the pharmaceutical industry to improve flowability and compactibility of powders. In this case our customer wanted to develop a new directcompression grade of excipient …
    Enabling the direct compression of metformin hydrochloride through QESD crystallization

    Enabling the direct compression of metformin hydrochloride through QESD crystallization

    Papers - 01/06/2021 - by Jerome Hansen, Peter Kleinebudde
    Metformin hydrochloride, employed in treating type 2 diabetes, exhibits notable challenges with poor flowability and agglomeration during storage, making direct compression into tablets a hitherto unsuccessful endeavor. A previous study …
    Melt granulation: A comparison of granules produced via high-shear mixing and twin-screw granulation

    Melt granulation: A comparison of granules produced via high-shear mixing and twin-screw granulation

    Papers - 14/10/2020 - by Kristina E. Steffens, Marvin B. Brenner, Michael U. Hartig, Marius Monschke, Karl G. Wagner
    Melt granules containing DI-CAFOS® A12 and 15% (w/w) Kolliphor® P407 were produced using a twin-screw granulator (TSG) under five different conditions (varied screw speed and throughput). These were then compared …
    High-molecular-weight hypromellose from three different suppliers: effects of compression speed, tableting equipment, and moisture on the compaction

    High-molecular-weight hypromellose from three different suppliers: effects of compression speed, tableting equipment, and moisture on the compaction

    Papers - 01/07/2020 - by Peter Grdešič, Amrit Paudel, Ilija German Ilić
    The increasing significance of higher tableting speeds in the pharmaceutical industry prompts a need for comprehensive studies on the mechanical properties of hypromellose. Surprisingly, there is a lack of recent …
    Powders flowability assessment in granular compaction: What about the consistency of Hausner ratio?

    Powders flowability assessment in granular compaction: What about the consistency of Hausner ratio?

    Papers - 01/09/2019 - by A. Saker, M.-G. Cares-Pacheco, P. Marchal, V. Falk
    This study evaluates powder flowability during granular compaction under free surface conditions, utilizing the Hausner ratio (HR) as the flowability index. Various pharmaceutical and food powders were scrutinized using three …
    Influence of spray nozzle aperture during high shear wet granulation on granule properties and its compression attributes

    Influence of spray nozzle aperture during high shear wet granulation on granule properties and its compression attributes

    Papers - 01/12/2018 - by Natalia Veronica, Hui Ping Goh, Christina Yong Xin Kang, Celine Valeria Liew, Paul Wan Sia Heng
    The distribution of granulating liquid is acknowledged to influence the high shear wet granulation process, but the impact of spray nozzle attributes remains unclear. While a spray nozzle can achieve …
    Engineered particles demonstrate improved flow properties at elevated drug loadings for direct compression manufacturing

    Engineered particles demonstrate improved flow properties at elevated drug loadings for direct compression manufacturing

    Papers - 01/05/2017 - by Andrea N. Trementozzi, Cheuk-Yui Leung, Frederick Osei-Yeboah, Erwin Irdam, Yiqing Lin, J. Michael MacPhee, Pierre Boulas, Shyam B. Karki, Peter N. Zawaneh
    Optimizing the powder flow and compaction properties is crucial to ensure a reliable tablet manufacturing process. The significance of the flow and compaction properties of the active pharmaceutical ingredient (API) …
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    Production of extended release mini-tablets using directly compressible grades of HPMC

    Papers - 01/11/2013 - by Faiezah A. A. Mohamed, Matthew Roberts, Linda Seton, James L. Ford, Marina Levina, Ali R. Rajabi-Siahboomi
    Background: Hypromellose (HPMC) has been utilized previously to regulate drug release in mini-tablets. However, due to suboptimal flow characteristics, the production of mini-tablets with elevated HPMC levels presents a challenge. …
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    Investigation into the impact of sub-populations of agglomerates on the particle size distribution and flow properties of conventional microcrystalline cellulose grades

    Papers - 01/10/2011 - by John F. Gamble, Wing-Sin Chiu, Mike Tobyn
    Microcrystalline cellulose (MCC) stands out as a highly adaptable tablet filler binder, widely employed in both granulation and direct compression processes. Previous research has revealed that MCC particle populations consist …