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Effect of binder type and lubrication method on the binder efficacy for direct compression

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1. Introduction : Addition of a binder to a direct compression formulation to increase tablet tensile strength and prevent tablets defects. Internal blending of magnesium stearate (MgSt) is often associated with decreasing tensile strengths and increasing disintegration times. -> Minimizing these negative effects with external lubrication. 2. Objective: Investigation of the effect of different binders and lubrication method on ejection force, tablet tensile strength and disintegration time of tablets produced through direct compression. Linking binder properties to tablet tensile strength and disintegration behavior, applying partial least square (PLS) analysis.
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