Scientific papers
This study aims to separate the effects of dwell time and strain rate on tablet strength and cracking behavior. Using a hydraulic compaction simulator, we isolated dwell time and strain rate from other parameters in the compaction cycle to study their independent contributions to tabletability. Dwell times ranged from 10 milliseconds to 100 seconds, and strain rates ranged from 1 to 100 per second. We used common excipients with various material attributes: microcrystalline cellulose (MCC), dibasic anhydrous calcium phosphate (DCP), and pregelatinized starch. The results showed that the impact of dwell time depends on the material and can enhance the tensile strength of compacts, but only at time scales beyond what is achievable on any rotary tablet press. Additionally, only MCC tablets formed cracks at high strain rates, with cracking partially improved only at extreme dwell times. When considering the dwell times achievable on a rotary press (10–100 milliseconds), the effects of dwell time were found to be minimal to non-existent, depending on the material. The effect of strain rate was also material-dependent but had a clear impact on tablet strength development and cracking behavior for MCC. Overall, the study found that dwell time and strain rate can affect tabletability; however, only strain rate influences are relevant for the rotary press.
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