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    Further enhancement of the sustained-release properties and stability of direct compression gel matrix bilayer tablets by controlling the particle size of HPMC and drug microencapsulation

    Further enhancement of the sustained-release properties and stability of direct compression gel matrix bilayer tablets by controlling the particle size of HPMC and drug microencapsulation

    Papers - 06/09/2024 - by Tong Liu, Jiahui Wang, Yupeng Feng, Haoran Wang, Yunlong Xu, Tian Yin, Yu Zhang, Haibing He, Jingxin Gou, Xing Tang
    The Theophylline and Salbutamol Bilayer Sustained-release Tablets (Yi Xi Qing®), produced using wet granulation, are prone to discoloration during long-term storage, and the manufacturing process is less consistent and more …
    Mannitol-coated hydroxypropyl methylcellulose as an alternative directly compressible

    Mannitol-coated hydroxypropyl methylcellulose as an alternative directly compressible controlled release excipient

    Newsfeeds - 28/08/2024 -
    One of the most common forms of controlled release technology for oral drug delivery involves dispersing an active ingredient in a hydrophilic matrix-forming polymer like hydroxypropyl methylcellulose (HPMC), which is …
    Image Fabrication and Optimization of Directly Compressible Self-Emulsifying Tablets Containing Cannabis Extract Obtained from Supercritical Carbon Dioxide Extraction

    Fabrication and optimization of directly compressible self-emulsifying tablets containing cannabis extract obtained from supercritical carbon dioxide extraction

    Newsfeeds - 15/04/2024 -
    The text discusses the challenges of low bioavailability of Tetrahydrocannabinol (THC) and Cannabidiol (CBD) in orally administered cannabis extract due to first-pass metabolism. It explores the use of a self-emulsifying …
    Impact of dry coating lactose as a brittle excipient on multi-component blend processability

    Impact of dry coating lactose as a brittle excipient on multi-component blend processability

    Papers - 20/02/2024 - by Zhixing Lin, Bian Cabello, Rajesh N. Davé
    Prior research has shown the advantages of applying dry coating to finely graded microcrystalline cellulose (MCC) to facilitate direct compression (DC), a preferred method in tablet manufacturing. This process enhances …
    Development of direct compression Acetazolamide tablet with improved bioavailability in healthy human volunteers enabled by cocrystallization with p-Aminobenzoic acid

    Development of direct compression Acetazolamide tablet with improved bioavailability in healthy human volunteers enabled by cocrystallization with p-Aminobenzoic acid

    Papers - 07/01/2024 - by Nimmy Kumari, Parag Roy, Sukanta Roy, Chenguang Wang, Sourav Das, Noopur Pandey, Susanta Kumar Mondal, Anirbandeep Bose, Changquan Calvin Sun, Animesh Ghosh
    Pharmaceutical cocrystallization is widely applied to enhance the physicochemical attributes of Active Pharmaceutical Ingredients (APIs). However, the formulation of cocrystals with demonstrated clinical success is currently limited. The successful translation …
    Elucidating the Impact of Material Properties on Tablet Manufacturability for Binary Paracetamol Blends

    Elucidating the impact of material properties on tablet manufacturability for binary paracetamol blends

    Papers - 17/11/2023 - by Lena Mareczek, Carolin Riehl, Meike Harms, Stephan Reichl
    Objective: While the mechanical properties of paracetamol and microcrystalline cellulose (MCC) are well-documented in the literature, there is a recognized need for a more nuanced understanding of the material properties …
    Enhancement of material attributes of poorly compressible metformin hydrochloride through coprocessing with hydroxypropyl cellulose (HPC-L) using coprecipitation (CPT)

    Enhancement of material attributes of poorly compressible metformin hydrochloride through coprocessing with hydroxypropyl cellulose (HPC-L) using coprecipitation (CPT)

    Papers - 06/11/2023 - by Kaushalendra Chaturvedi, Pasaorn Pongkulapa, Xiaoyi Ding, Harsh S. Shah, San Kiang, Veeran Kadajji
    Coprocessing entails integrating multiple substances to enhance the physical, chemical, mechanical, and biopharmaceutical properties of a material. It stands as a promising technique in the pharmaceutical industry, supporting both drug …
    The Development of Oral Solid Dosage Forms Using the Direct-Compression Tableting of Spray-Dried Bacteriophages Suitable for Targeted Delivery and Controlled Release

    The development of oral solid dosage forms using the direct-compression tableting of spray-dried bacteriophages suitable for targeted delivery and controlled release

    Papers - 03/11/2023 - by Zahra Rezaie Yazdi, Mark C. Leaper, Danish J. Malik
    This study tackles the challenge of creating an affordable, patient-friendly alternative to antibiotics for gastrointestinal applications, utilizing bacteriophages. The research investigates the possibility of producing an enteric solid dosage form …
    Challenges in the Transfer and Scale-Up of Mini-Tableting: Case Study with Losartan Potassium

    Challenges in the transfer and scale-up of mini-tableting: case study with Losartan Potassium

    Papers - 09/10/2023 - by Valentinë Lura, Stefan Klinken, Jörg Breitkreutz
    Mini-tablets (MTs) containing losartan potassium were developed for the treatment of the rare disease Epidermolysis Bullosa. The primary focus was on the transfer and scale-up of a direct compressible formulation …
    Impact of material properties and process parameters on tablet quality in a continuous direct compression line

    Impact of material properties and process parameters on tablet quality in a continuous direct compression line

    Papers - 05/04/2023 - by Pauline H.M. Janssen, Sara Fathollahi, Bram Bekaert, Dirk Vanderroost, Timo Roelofs, Valerie Vanhoorne, Chris Vervaet, Bastiaan H.J. Dickhoff
    This paper demonstrates the influence of excipient properties on both process parameters and the ultimate tablet properties in a fully integrated continuous direct compression line. The blend properties of low-dose …
    Multivariate data analysis to evaluate commonly used compression descriptors

    Multivariate data analysis to evaluate commonly used compression descriptors

    Papers - 27/03/2023 - by Sabrina Berkenkemper, Stefan Klinken, Peter Kleinebudde
    Numerous studies have delved into material behavior through compression analyses, with a particular emphasis on compressibility, compactibility, and tabletability. In this study, an extensive multivariate data analysis was conducted using …
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    Effect of process parameters, protectants and carrier materials on the survival of yeast cells during fluidized bed granulation for tableting

    Papers - 09/03/2023 - by Karl Vorländer, Lukas Bahlmann, Arno Kwade, Jan Henrik Finke, Ingo Kampen
    This study focuses on the drying of Saccharomyces cerevisiae, a yeast variety that includes the probiotic Saccharomyces boulardii. Ensuring microbial viability is crucial for effective dosage forms, especially for probiotics …
    Evaluation of alternative methods to derive particle density from compression data

    Evaluation of alternative methods to derive particle density from compression data

    Papers - 03/01/2023 - by Sabrina Berkenkemper, Peter Kleinebudde
    Determining particle density is a crucial aspect of material characterization, particularly in compression analyses. Helium pycnometry, the most commonly used method, has faced criticism for various reasons, with a notable …
    Upscaling of external lubrication from a compaction simulator to a rotary tablet press

    Upscaling of external lubrication from a compaction simulator to a rotary tablet press

    Papers - 01/01/2023 - by Cedrine de Backere, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    External lubrication is a highly valuable alternative lubrication method as it minimizes the negative impact on tablet properties encountered when using internal lubrication. In current study, experiments were performed with …
    Screening of lubricants towards their applicability for external lubrication

    Screening of lubricants towards their applicability for external lubrication

    Papers - 28/12/2022 - by Cedrine de Backere, Margot Surmont, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    Decreasing tensile strength and prolonged disintegration are linked to internal lubrication. These adverse effects can be mitigated by employing external lubrication. In this present investigation, a compaction simulator was utilized …
    Poly(2-alkyl-2-oxazoline)s: A polymer platform to sustain the release from tablets with a high drug loading

    Poly(2-alkyl-2-oxazoline)s: A polymer platform to sustain the release from tablets with a high drug loading

    Papers - 01/12/2022 - by Aseel Samaro, Maarten Vergaelen, Martin Purino, Ali Tigrine, Victor R. de la Rosa, Niloofar Moazami Goudarzi, Matthieu N. Boone, Valérie Vanhoorne, Richard Hoogenboom, Chris Vervaet
    Achieving sustained release of highly dosed active pharmaceutical ingredients (APIs) from a matrix tablet poses a significant challenge. To tackle this issue, this study assessed the efficacy of thermoplastic poly(2-alkyl-2-oxazoline)s …
    Alginate ester: New moisture-scavenging excipients for direct compressible pharmaceutical tableting

    Alginate ester: new moisture-scavenging excipients for direct compressible pharmaceutical tableting

    Papers - 01/12/2022 - by Noelia M. Sanchez-Ballester, Philippe Trens, Jean-Christophe Rossi, Ian Soulairol
    This study aims to assess methyl ester alginates and alginic acid (AA) as moisture-scavenging excipients for formulating aspirin tablets through direct compression. The tablets underwent storage under accelerated conditions (40 …
    Improving the Manufacturability of Cohesive and Poorly Compactable API for Direct Compression of Mini-tablets at High Drug Loading via Particle Engineering

    Improving the manufacturability of cohesive and poorly compactable API for direct compression of mini-tablets at high drug loading via particle engineering

    Papers - 01/11/2022 - by Liang Chen, Yiqing Lin, Erwin Irdam, Nicole Madden, Frederick Osei-Yeboah
    The aim is to employ a particle engineering approach to enhance the manufacturability of a cohesive and challenging-to-compact active pharmaceutical ingredient (API) with a high drug loading, specifically for the …
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    Understanding the multidimensional effects of polymorphism, particle size and processing for D-Mannitol powders

    Papers - 07/10/2022 - by Lena Mareczek, Carolin Riehl, Meike Harms, Stephan Reichl
    This study investigated the influence of polymorphic form, particle size, and processing of mannitol on the mechanical properties of solid oral dosage forms. The particle and powder properties of spray …
    Impact of Lubrication on Key Properties of Orodispersible Minitablets in Comparison to Conventionally Sized Orodispersible Tablets

    Impact of lubrication on key properties of orodispersible minitablets in comparison to conventionally sized orodispersible tablets

    Papers - 05/09/2022 - by Jennifer Kuck, Jörg Breitkreutz
    Orodispersible minitablets (ODMTs) offer several advantages such as ease of swallowability, dose flexibility, and straightforward manufacturing through direct compression. This study investigates the impact of lubrication on five different co-processed …