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    Tablet_Minitablet_vs_tablet_1

    Development of mini-tablet and multi-unit pellet systems (MUPs)

    Newsfeeds - 24/05/2024 -
    The text discusses the development and benefits of Mini-Tablet and Multi-Unit Pellet Systems (MUPS) in oral drug delivery. These advanced dosage forms offer controlled and sustained release profiles, achieved through …
    Study of compaction tools and parameters on critical quality attributes of high drug load minitablets

    Study of compaction tools and parameters on critical quality attributes of high drug load minitablets

    Papers - 05/03/2024 - by Shang Jun Loo, Cheng Yee Lim, Paul Wan Sia Heng, Lai Wah Chan
    Minitablets are created through the utilization of multiple die openings and multi-tip punches to enhance productivity. Typically, the total compaction force required is determined by multiplying the desired force per …
    Tableting of coated multiparticulates: Influences of punch face configurations

    Tableting of coated multiparticulates: Influences of punch face configurations

    Papers - 01/03/2024 - by Daniel Robin Thio, Natalia Veronica, Paul Wan Sia Heng, Lai Wah Chan
    The impact of punch face design on multi-unit pellet system (MUPS) tablets was examined in this study. Drug-loaded pellets, coated with sustained-release polymers such as ethylcellulose or acrylic, were compacted …
    Challenges in the Transfer and Scale-Up of Mini-Tableting: Case Study with Losartan Potassium

    Challenges in the transfer and scale-up of mini-tableting: case study with Losartan Potassium

    Papers - 09/10/2023 - by Valentinë Lura, Stefan Klinken, Jörg Breitkreutz
    Mini-tablets (MTs) containing losartan potassium were developed for the treatment of the rare disease Epidermolysis Bullosa. The primary focus was on the transfer and scale-up of a direct compressible formulation …
    Improving the Manufacturability of Cohesive and Poorly Compactable API for Direct Compression of Mini-tablets at High Drug Loading via Particle Engineering

    Improving the manufacturability of cohesive and poorly compactable API for direct compression of mini-tablets at high drug loading via particle engineering

    Papers - 01/11/2022 - by Liang Chen, Yiqing Lin, Erwin Irdam, Nicole Madden, Frederick Osei-Yeboah
    The aim is to employ a particle engineering approach to enhance the manufacturability of a cohesive and challenging-to-compact active pharmaceutical ingredient (API) with a high drug loading, specifically for the …
    Impact of Lubrication on Key Properties of Orodispersible Minitablets in Comparison to Conventionally Sized Orodispersible Tablets

    Impact of lubrication on key properties of orodispersible minitablets in comparison to conventionally sized orodispersible tablets

    Papers - 05/09/2022 - by Jennifer Kuck, Jörg Breitkreutz
    Orodispersible minitablets (ODMTs) offer several advantages such as ease of swallowability, dose flexibility, and straightforward manufacturing through direct compression. This study investigates the impact of lubrication on five different co-processed …
    Charge reduction assisted production of diminutive fluid bed granules for high drug load minitablets

    Charge reduction assisted production of diminutive fluid bed granules for high drug load minitablets

    Papers - 25/07/2022 - by Shang Jun Loo, Paul Wan Sia Heng, Lai Wah Chan
    Micronized drug powders are often impractical for use as tableting feed to create minitablets due to their cohesiveness and poor flow properties. The addition of fumed silica (fSi) within an …
    Manufacturing of mini-tablets. Focus and impact of the tooling systems

    Manufacturing of mini-tablets. Focus and impact of the tooling systems

    Papers - 29/04/2022 - by Ard Lura, Jörg Breitkreutz
    Mini-tablets are gaining significance in the pharmaceutical industry, particularly for special patient groups like pediatrics, as highlighted in various clinical studies and by organizations. These mini-tablets can be produced on …
    Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa

    Pharmaceutical development of film-coated mini-tablets with losartan potassium for Epidermolysis Bullosa

    Papers - 05/03/2022 - by Valentinë Elezaj, Ard Lura, Luis Canha, Jörg Breitkreutz
    Epidermolysis bullosa is a genetically heterogeneous skin fragility disorder that manifests with multiorgan involvement, often evident in newborn children. The condition leads to severe progressive fibrosis following skin blistering, mucosal …
    Transfer and scale-up of the manufacturing of orodispersible mini-tablets from a compaction simulator to an industrial rotary tablet press

    Transfer and scale-up of the manufacturing of orodispersible mini-tablets from a compaction simulator to an industrial rotary tablet press

    Papers - 23/07/2021 - by Ard Lura, Valentinë Elezaj, Marcel Kokott, Björn Fischer, Jörg Breitkreutz
    Orodispersible mini-tablets (ODMTs) are emerging as a promising pediatric dosage form, garnering increased attention from the pharmaceutical industry. However, the process of scaling up ODMTs from a compaction simulator to …
    20201209_Webinar_R&D_of_mini-tablets_with_STYL'One_Evo

    R&D of mini-tablets on a STYL'One Evo

    Webinar Replays - 12/12/2020 - by Ard Lura
    Ard Lura's enlightening webinar on the formulation of mini-tablets.
    Tableting of mini-tablets in comparison with conventionally sized tablets: A comparison of tableting properties and tablet dimensions

    Tableting of mini-tablets in comparison with conventionally sized tablets: A comparison of tableting properties and tablet dimensions

    Papers - 01/12/2020 - by Ard Lura, Guillaume Tardy, Peter Kleinebudde, Jörg Breitkreutz
    Mini-tablets, increasingly attractive in the pharmaceutical industry for their clinical and biopharmaceutical advantages, lack a comprehensive investigation of technological aspects. This study delves into the impact of punch size and …
    Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering

    Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering

    Papers - 01/01/2020 - by Leonie Wagner-Hattler, Gabriela Québatte, Jennifer Keiser, Joachim Schoelkopf, Christian M. Schlepütz, Jörg Huwyler, Maxim Puchkov
    Ensuring uniform drug distribution within rapidly disintegrating tablets is a critical quality criterion for achieving a consistent, controlled, and targeted release of the active pharmaceutical ingredients they contain. This study …
    A mechanistic understanding of compression damage to the dissolubility of coated pellets in tablets

    A mechanistic understanding of compression damage to the dissolubility of coated pellets in tablets

    Papers - 01/01/2020 - by Tze Ning Hiew, Yu Harn Tian, Huei Ming Tan, Paul Wan Sia Heng
    The potential harm to the drug diffusion coat barrier of controlled-release pellets due to compaction force during the preparation of multiple-unit pellet system tablets is a significant concern. Prior research …
    Glibenclamide mini-tablets with an enhanced pharmacokinetic and pharmacodynamic performance

    Glibenclamide mini-tablets with an enhanced pharmacokinetic and pharmacodynamic performance

    Papers - 01/10/2018 - by Hesham M. Tawfeek, Matthew Roberts, Mohamed A. El Hamd, Ahmed A. H. Abdellatif, Mahmoud A. Younis
    In an effort to reduce the dosage, anticipated side effects, and production costs of glibenclamide (GLC), a potent oral hypoglycemic drug, the study aimed to enhance dissolution and, consequently, oral …
    Evaluation of disintegrants functionality for orodispersible mini tablets

    Evaluation of disintegrants functionality for orodispersible mini tablets

    Papers - 02/11/2017 - by Ian Soulairol, Mohammad Chaheen, Nicolas Tarlier, Adrien Aubert, Bernard Bataille, Tahmer Sharkawi
    Objective: This study aims to assess the performance of various superdisintegrants (SD) in the production of orodispersible mini tablets (ODMT) through direct compression. Methods: Twenty-three formulations, varying in SD type, …
    CombiCap: A novel drug formulation for the basel phenotyping cocktail

    CombiCap: A novel drug formulation for the basel phenotyping cocktail

    Papers - 15/10/2016 - by Marine Camblin, Benjamin Berger, Manuel Haschke, Stephan Krähenbühl, Jörg Huwyler, Maxim Puchkov
    Phenotyping of cytochrome P450 isoenzymes serves for metabolic profiling, typically involving the administration of phenotyping cocktails consisting of individual marketed products. However, these cocktails are not specifically designed for diagnostic …
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    In silico and in vitro methods to optimize the performance of experimental gastroretentive floating mini-tablets

    Papers - 03/05/2016 - by Veronika A. Eberle, Armella Häring, Joachim Schoelkopf, Patrick A. C. Gane, Jörg Huwyler, Maxim Puchkov
    Background: Developing floating drug delivery systems (FDDS) is a complex task. To simplify this process, a method was introduced for the simultaneous assessment of drug release and flotation. Objective: The …
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    Production of extended release mini-tablets using directly compressible grades of HPMC

    Papers - 01/11/2013 - by Faiezah A. A. Mohamed, Matthew Roberts, Linda Seton, James L. Ford, Marina Levina, Ali R. Rajabi-Siahboomi
    Background: Hypromellose (HPMC) has been utilized previously to regulate drug release in mini-tablets. However, due to suboptimal flow characteristics, the production of mini-tablets with elevated HPMC levels presents a challenge. …
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    The influence of HPMC concentration on release of theophylline or hydrocortisone from extended release mini-tablets

    Papers - 01/08/2013 - by Faiezah A. A. Mohamed, Matthew Roberts, Linda Seton, James L. Ford, Marina Levina, Ali R. Rajabi-Siahboomi
    Context: Mini-tablets, compact dosage forms typically 2–3 mm in diameter, offer potential advantages for paediatric drug delivery. Extended-release (ER) oral dosage forms aim to provide controlled drug release for prolonged …