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Thermal and Compaction Behavior of Spray-Dried Itraconazole- HPMCAS Dispersions

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Hydroxypropyl methylcellulose acetate succinate (HPMCAS), characterized as an anionic polymer, finds diverse applications in drug delivery. Its utility extends to serving as a carrier for amorphous spray-dried dispersions (SDDs), thereby improving the solubility of BCS Class II compounds such as Itraconazole (ITZ). However, the specific grades of HPMCAS and the levels of drug loadings can significantly impact the formulation. This study aims to evaluate the effects of HPMCAS grades and drug loadings on both thermal and compaction profiles.
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