Assessment of the plasticity of dry granulated particles

November 28, 2025

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The article discusses how dry‑granulated particles, especially those obtained via roller compaction or slugging, play a crucial role in tablet manufacturing. It highlights that a granule’s ability to undergo plastic deformation—rather than simply breaking apart—is a key factor influencing tabletability (i.e., how well the granules compress into a robust tablet). The study with mixtures of microcrystalline cellulose (MCC) and α‑lactose monohydrate (LAC) found that higher MCC proportions increased granule deformability and tablet tensile strength, but only up to a point; when fragmentation was very limited, the benefit diminished. Overall, the work underlines that granule plasticity should be assessed during formulation development for dry‑granulated systems to ensure a reliable route to tableting.