Coating monitoring of pediatric minitablets

January 16, 2026

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The article reports on a study using Optical Coherence Tomography (OCT) as a process analytical technology (PAT) to monitor coating quality on pediatric minitablets, which are small‑diameter tablets (<3 mm) designed to improve swallowing and dosing flexibility for children. OCT was used to measure the thickness and structure of the coating layer on both placebo and API‑loaded minitablets during the coating process. Results showed that coating thickness increased over time in both types, with API‑loaded cores exhibiting a faster increase due to higher solid content. OCT could automatically detect coating layer changes quickly and accurately, making it a promising technology for inline monitoring of minitablet coating processes. This approach could help ensure consistent drug release and dose uniformity in pediatric minitablet production