Ebook: Twin-screw extrusion for pharmaceutical applications

July 03, 2024

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This compendium provides a comprehensive guide on how hot-melt extrusion (HME) can address common challenges in pharmaceutical development. It offers detailed guidance on all stages of the HME process, from formulation characterization to process design, development, and downstream processing.

Hot-melt extrusion is an effective technique for pharmaceutical formulation, enabling the compounding of all excipients at a molecular level. Using a twin-screw extruder and corresponding downstream equipment, various dosage forms can be produced. These include solid oral dosage forms such as buccal and transdermal, as well as innovative delivery systems like subcutaneous implants and transmucosal applications.

Download this eBook to access a collection of articles that:

- Introduce hot-melt extrusion and twin-screw extrusion

- Explain the benefits of HME over spray drying

- Outline the key information required for successful extrusion trials

- Discuss HME process design and development

- Explore the different dosage forms that can be created using the twin-screw extrusion process.