Fabrication and optimization of directly compressible self-emulsifying tablets containing cannabis extract obtained from supercritical carbon dioxide extraction

April 15, 2024

Remove from favorites

Add to favorites

The text discusses the challenges of low bioavailability of Tetrahydrocannabinol (THC) and Cannabidiol (CBD) in orally administered cannabis extract due to first-pass metabolism. It explores the use of a self-emulsifying drug delivery system (SEDDS) to improve dissolution and bioavailability, but liquid formulations face stability issues. To tackle this, the study develops solid SEDDS tablets containing cannabis extract. The process involves solidifying a liquid SEDDS with solid carriers, optimizing tablet formulation factors, and compressing them into tablets. Results show successful solidification of the mixture and optimal tablet formulation without certain excipients. The tablets demonstrate improved dissolution of the cannabis extract, particularly THC, and can emulsify small droplets. Despite slightly larger droplet sizes compared to liquid SEDDS, the study concludes that the developed tablets effectively enhance the dissolution of cannabis extract.