Formulation handbook from Merck

October 02, 2025

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Formulating the perfect dosage form is no easy task. With so many techniques and excipients available, every decision made during development can influence the performance and success of the final product.

That’s why we created this formulation handbook—a practical resource packed with model formulations and technical insights to support you in your own projects. Using model APIs and well-established techniques, the handbook walks you through how to design and manufacture a wide range of dosage forms.

Inside, you’ll find examples covering popular tableting methods like direct compression, wet granulation, and dry granulation, along with advanced approaches such as solubility enhancement, modified release systems, and even additive manufacturing. We also highlight solutions for various product types, from immediate- and sustained-release tablets to ODTs, chewables, lozenges, and tablet coatings.

Whether you’re just starting out or looking to refine your process, our model formulations can serve as a roadmap to help you turn development challenges into successful pharmaceutical products.