Experimental and theoretical design on the development of matrix tablets with multiple drug loadings aimed at optimizing antidiabetic medication
This study focuses on developing extended-release polymeric matrix tablets containing metformin hydrochloride (M-HCl) and honokiol (HNK) to improve diabetes treatment. Using hydrophilic polymers like Carbopol® 71G NF and Noveon® AA-1, the researchers investigated the release kinetics of the drugs through advanced mathematical models and traditional kinetic models.
Key Findings:
- Distinct Release Profiles: M-HCl showed a rapid release, with 80% released within 4–7 hours, while HNK had a slower release, reaching 80% after 9–10 hours.
- Polymer Concentration Impact: Higher polymer concentrations slowed drug release due to gel-like structure formation.
- Mathematical Modeling: Validated experimental findings and provided insights into drug release mechanisms.
- Tablet Suitability: The mechanical properties and stability confirmed the tablets' suitability for extended-release applications.
The study highlights the potential of these formulations to enhance patient compliance and therapeutic outcomes in diabetes management.
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