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Diluent Effects On Drug Release From Sustained Release Compritol® 888 ATO Tablets

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Glyceryl behenate, known as Compritol® 888 ATO, is frequently employed in the formulation of sustained-release lipid matrices. Upon compression, Compritol® 888 ATO establishes an insoluble network structure, facilitating water penetration and subsequent drug release through diffusion. The objective was to evaluate the impact of different diluents on the release of the soluble drug, theophylline, from Compritol® 888 ATO matrices. These matrices were produced through direct compression under simulated production conditions using a Stylcam® 100R rotary press simulator.
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