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    Defects in tablet production KORSCH

    Understanding the powder compression phase - and avoiding tablet defects

    White Papers - 14/10/2024 -
    From Vincent Mazel, 19.06.2024The tableting process looks simple, but is complex and irreversible: the University of Bordeaux is learning together with the tableting specialists.Expert in physics and mechanics, highly regarded …
    Image CMAC STYL'One Nano

    From product development to quality control

    White Papers - 11/09/2024 - by Daniel Markl
    A multidisciplinary team at the University of Strathclyde is working on the transformation of the development of pharmaceutical tablets through the use of industrial digital technologies.The “Made Smarter Innovation – …
    I Holland tooling

    Saving time and money by selecting the correct anti-abrasive solution

    White Papers - 28/08/2024 -
    Thompson & Capper is a contract manufacturer of pharmaceutical and nutritional tablets, based in the UK. They produce over 2.5 billion tablets every year, mainly for clients in Europe.Thompson & …
    STYL'One Evo WipCon OEB 5

    Containment is a growing demand in R&D tableting equipment

    White Papers - 11/07/2024 - by Bruno Villa
    The principle “better safe than sorry” is now widely applied in containment, mainly due to the following key factors.The number one factor is the stringent Labor Protection Law. An increase …
    On Top Form - Nutraceutical Manufacturing - Feb 2014

    On top form - the production of nutraceutical tablets

    White Papers - 05/07/2024 - by Rob Blanchard, Trevor Higgins
    The production of nutraceuticals in tablet form demands detailed exploration. Manufacturing challenges and increasingly strict regulations must be considered right from product conception, in order to prevent downstream development issues.
    Image - Article I Holland GR lanes

    Working with GR Lanes Health Products Ltd.

    White Papers - 23/04/2024 -
    Lanes, is a leading UK family-owned pharmaceutical company that specialises in producing natural remedies and is famous for brands such as Olbas and Kalms. Market leading products like these demand …
    Illustration systems engineering for high containment

    Systems engineering for high containment

    White Papers - 27/03/2024 - by Johannes Nitzsche
    Planning a fully integrated tablet compression system for high-containment requires extensive know-how and experience. “Not only is the tablet press itself affected by the more stringent safety precautions at each …
    close-up-hand-holding-pills

    High-speed nutraceutical production

    White Papers - 19/03/2024 - by Nerea Arcaraz
    The sanotact Group opts to use KORSCH machinery for volume production purposes and is a launch customer for the new X5 high-speed single-sided rotary press.The sanotact Group is a manufacturer …
    multi tip tooling KORSCH

    On the use of multi-tip tools

    White Papers - 23/02/2024 - by Fred Murray
    The prospect of using multi-tip tools to dramatically increase production output on a single tablet press has long been considered by process engineers who seek additional capacity with minimal capital …
    Image IHolland tableting multi tip tooling

    Tabletting - Multiple choice

    White Papers - 21/02/2024 - by Steve Osborn
    Steve Osborn asks whether multi-tip tooling is a key driver to increasing tablet production.The manufacture of oral solid dosage forms has had to progress rapidly to keep pace with the …
    Chip to swallow

    Smart tablets

    White Papers - 15/02/2024 - by Helmut Zeddies
    A micro-chip confirms that a tablet has been taken: KORSCH technology makes it happen.Nearly half of all patients don’t take their medication as prescribed. Some don’t take it at all. …
    MUPS KORSCH technology blog

    MUPS - the mixture is what matters

    White Papers - 06/02/2024 - by Friederike Guetter
    MUPS, or “multiple unit pellet system”, is a solid dosage form in which the granulation consists of a mixure of active, coated pellets and powder excipients. MUPS products include, for …
    Rotary tablet press - KORSCH

    The critical role of product die filling

    White Papers - 01/02/2024 - by Friederike Guetter
    Product flow and consistent die filling are essential factors for successful tableting. For successful tablet production, many process steps must be harmonized with each other.
    Effervescent-tablet-white-iStock-95934093 Bubbles-2

    Effervescent tablets - the tempest in a tumbler

    White Papers - 31/01/2024 - by Jean Yves Balfin
    Effervescent tablets are used for antacids and to treat common cold complaints, yet they also have food supplement and multi-vitamin delivery applications and can be used to clean teeth and …
    Image process optimization specialists korsch

    Process optimization by the Specialists

    White Papers - 23/01/2024 - by Fred Murray
    There is increased pressure on pharmaceutical manufacturers to realize gains in efficiency, capacity, and product quality. The KORSCH Global Customer Care Team draws on its worldwide experience to provide comprehensive …
    Image Continuous production KORSCH LB Bohle

    Continuously good

    White Papers - 10/01/2024 - by Jean Yves Balfin
    Batch or continuous? Both processes have their advantages. Batch has been the standard process in the pharmaceutical industry to date, but continuous processes provide some appealing benefits.
    KORSCH Innovation Center Machine Control Panel

    Digitalization of tablet presses

    White Papers - 04/01/2024 - by Jean Yves Balfin
    The purpose of this paper is to explain how KORSCH is configuring our equipment and supporting our customers as we work collectively toward Industry 4.0.
    Image Korsch BASF understanding of materials

    Everything starts with an understanding of the materials

    White Papers - 18/12/2023 -
    Simulators and software solutions provide valuable product development support when appropriate raw materials need to be selected.Sound knowledge of the active pharmaceutical ingredient (API) to be formulated and the required …
    Correct tool specification are key to success iHolland mod

    Choosing the correct tool material specification

    White Papers - 14/12/2023 -
    Michael Oxford, Research and Design Engineer at I Holland explains how I Holland recently helped pharma group Accord Healthcare improve tablet production.
    Medelpharm Science Lab tests under hood

    On the trail of solubility

    White Papers - 14/12/2023 -
    From Korbinian Löbmann | Søren Vinter Søgaard, 02.11.2022Innovative, Copenhagen-based startup Zerion Pharma utilizes the equipment and know-how of the MEDELPHARM INNOVATION CENTER (called “Science Lab” in France) for product development …
    Compaction simulator & scientist

    Why use a compaction simulator?

    White Papers - 30/11/2023 - by Bruno Leclercq
    Development of pharmaceutical dosage forms requires the careful characterization and under-standing of the formulation, including active pharmaceutical ingredients (APIs) and excipients, and of the compression process.One of the most significant …
    KORSCH Scale-up

    From development phase to serial production

    White Papers - 29/11/2023 - by Johny Bertels
    Scale-up is the last step on the way to commercial tablet production. Once formulation and clinical trial phases have been successfully completed, this final phase involves scaling up to serial …
    Extended Dwell Flat (XDF) tooling at IHolland

    Timing is key in tabletting

    White Papers - 29/11/2023 -
    Why you need to get your timing right to make better tabletsNeed to mass-produce tablets with quality solid dosage in a quick and cost-effective way? The time that a formulation …
    I Holland Test 2

    Successful cooperation yields - anti-stick rewards with Pfizer

    White Papers - 21/11/2023 -
    Sticking is one of the biggest production challenges faced by tablet manufacturers. This article clarifies the challenge and outlines solutions on how to resolve sticking to ensure it is not …
    I Holland Test 2

    How to avoid sticky situations

    White Papers - 10/10/2023 -
    Sticking is one of the biggest production challenges faced by tablet manufacturers. This article clarifies the challenge and outlines solutions on how to resolve sticking to ensure it is not …
    Material-Sparing-Method-for-Dry-Granulation.original

    Dry granulation a material sparing method

    White Papers - 01/08/2023 - by Bruno Villa
    Granulation of pharmaceutical powder is often required to prevent segregation of the Active Pharmaceutical Ingredient (API) and/or to enhance the blend flowability, which is critical to ensure consistent tablet mass …
    capsules_filled.original

    An introduction to spheronization (or marumerization)

    White Papers - 14/02/2023 -
    Spheronization (or marumerization) is the process where extrudates (the output from an extruder) are shaped into small rounded or spherical granules. In practice these usually vary in size from 0.4 …
    ME-092-EN-A_Tableting_Rheology_and_Quality_by_D.original

    Tableting rheology and quality by design

    White Papers - 18/01/2023 -
    Quality by Design (QbD) in tablet development can be challenging, due to the multiple competing technological aims, such as flow, compactability, lubrication and drug release. Tablets are complex and, whether …
    process scale-up

    How to mitigate risks in process scale-up ?

    Newsfeeds - 18/07/2022 -
    With the ever-rising costs of bringing a drug to market, pharmaceutical companies are increasingly looking at how they can improve the efficiency of their entire product development and drug commercialisation …
    tablet_defect.original

    Troubleshooting tablet defects in no-time

    White Papers - 12/10/2021 - by Bruno Leclercq
    There are numerous tablet defects: chipping, picking & sticking, cracking, lamination & capping to name a few.Lamination & capping often occur during scale-up and are main issues in our industry. …
    Lubrication-now-easy-to-use-for-RD-lab-environm.original

    Lubrication now easy-to-use for R&D lab environment

    White Papers - 02/07/2021 - by Bruno Leclercq
    Lubricants are often required to minimize friction between a tablet surface and the die walls during the ejection phase of the compression cycle. In turn the reduced friction minimizes the …
    Tablet_Multilayer_15_HD.original

    Key considerations in multilayer tableting

    White Papers - 15/06/2021 - by Jean Yves Balfin
    The manufacturing of multilayer tablets may seem to be simple duplications of the basic single-layer compression cycle, but in reality, the process is far more complicated. In this article, KORSCH …
    XP 1 - STYL'One Nano - STYL'One Evo

    Tableting scale-up challenges

    White Papers - 15/06/2021 - by Friederike Guetter
    The manufacturing of multilayer tablets may seem to be simple duplications of the basic single-layer compression cycle, but in reality, the process is far more complicated. In this article, KORSCH …