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    news fundamentals of particle size analysis

    Fundamentals of particle size analysis

    Newsfeeds - 19/05/2025 -
    The article from Outsourced Pharma, sourced from Catalent, explains that particle size analysis is essential in pharmaceutical development because it influences drug dissolution, bioavailability, and efficacy. Modern techniques like laser …
    In Vitro-In Vivo Correlation Of Amorphous Solid Dispersion Enabled Itraconazole Tablets

    In vitro-in vivo correlation of amorphous solid dispersion enabled itraconazole tablets

    Papers - 11/03/2025 - by Ana L. Coutinho, Asmita Adhikari, Samuel Krug, Maureen Kane, R. Gary Hollenbeck, Stephen W. Hoag, James E. Polli
    Purpose: This study addresses the lack of reports on in vitro-in vivo correlation (IVIVC) model development for immediate-release (IR) formulations and the limited investigation of formulation and process impacts on …
    A comparative study of two data-driven modeling approaches to predict drug release from ER matrix tablets

    A comparative study of two data-driven modeling approaches to predict drug release from ER matrix tablets

    Papers - 16/01/2025 - by A.S. Sousa, J. Serra, C. Estevens, R. Costa, A.J. Ribeiro
    The pharmaceutical industry is increasingly adopting innovative, data-driven tools to enhance, optimize, and accelerate the drug development process. Extended-release (ER) oral formulations offer numerous benefits, such as maintaining therapeutic drug …
    Real-time prediction of dissolution profiles of coated oral dosage forms

    Real-time prediction of dissolution profiles of coated oral dosage forms

    Papers - 21/10/2024 - by Stephan Sacher, Elisabeth Fink, Carolina Alva, Jesús Alberto Afonso Urich, Aygün Doğan, Vanessa Herndler, Ioannis Koutsamanis, Varun Kushwah, Anna Peter, Sharareh Salar-Behzadi, Katrina Wilfling, Sandra Stranzinger, Manuel Zettl, Xin Feng, Maxwell Korang-Yeboah, Huiquan Wu, Johannes G. Khinast
    Optical coherence tomography (OCT) has become an in-line monitoring method for pharmaceutical coating processes based on a representative sample size. In this study, a method was developed to correlate coating …
    Image flexible modelling of the dissolution performance of directly compressed tablets

    Flexible modelling of the dissolution performance of directly compressed tablets

    Newsfeeds - 08/10/2024 -
    This study proposes a compartmental disintegration and dissolution model to predict and evaluate the dissolution behavior of directly compressed tablets. The model consists of three compartments (Bound, Disintegrated, and Dissolved) …
    Image Efficient Development Of Oral Drug Products Selecting A Dissolution Media

    Efficient development of drug products: selecting a dissolution media

    Newsfeeds - 24/07/2024 -
    The article discusses the importance of selecting the appropriate dissolution media in the efficient development of oral drug products. Dissolution testing is crucial for evaluating the release rate of a …
    image - Real-world dosing solutions for patients

    Real world dosing solutions for patients

    Newsfeeds - 18/06/2024 -
    Discover how fast dissolve technology can offer dosing solutions for different patient populations.Zydis® ODT (orally dissolving tablet) is a distinctive, freeze-dried oral solid dosage form that dissolves almost immediately in …
    In-line porosity and hardness monitoring of tablets by means of optical coherence tomography

    In-line porosity and hardness monitoring of tablets by means of optical coherence tomography

    Papers - 12/05/2024 - by Elisabeth Fink, Selma Celikovic, Rúben Martins Fraga, Johan Remmelgas, Jakob Rehrl, Johannes Khinast
    "Monitoring critical quality attributes (CQAs) in-line during the tableting process is crucial for implementing a real-time release strategy. CQAs such as tablet mass, API content, dissolution, hardness, and tensile strength …
    New Hydrophilic Matrix Tablets for the Controlled Released of Chlorzoxazone

    New hydrophilic matrix tablets for the controlled released of chlorzoxazone

    Papers - 09/05/2024 - by Andreea Creteanu, Gabriela Lisa, Cornelia Vasile, Maria-Cristina Popescu, Daniela Pamfil, Claudiu N. Lungu, Alina Diana Panainte, Gladiola Tantaru
    The controlled release of active ingredients like chlorzoxazone from matrix tablets, utilizing Kollidon®SR and chitosan, relies on both the drug's solubility in the dissolution medium and the composition of the …
    Elucidating the effect of salt incorporation in tablets on tablet disintegratability

    Elucidating the effect of salt incorporation in tablets on tablet disintegratability

    Papers - 04/01/2024 - by Audrey Yi Zheng, Yuan Wei Liau, Paul Wan Sia Heng, Lai Wah Chan
    The breakdown of tablets is vital for promoting drug release, and disintegrants are utilized in tablet formulations to enhance this process. This study aimed to investigate the influence of incorporating …
    Characterizing interspecies differences in gastric fluid properties to improve understanding of in vivo oral drug formulation performance

    Characterizing interspecies differences in gastric fluid properties to improve understanding of in vivo oral drug formulation performance

    Papers - 02/02/2023 - by Kristina R. Rivera, Jenni Pessi, Vincent Andersson, Henning Gustafsson, Lise Lotte Gluud, Stephen T. Buckley
    A comprehensive understanding of the properties of gastric fluid(s) before an in vivo pharmacokinetic investigation can significantly enhance the accuracy of predictions regarding in vivo performance. Previous characterizations of animal …
    Surface Characterization as a Tool for Identifying the Factors Affecting the Dissolution Rate of Amorphous Solid Dispersion Tablets

    Surface characterization as a tool for identifying the factors affecting the dissolution rate of amorphous solid dispersion tablets

    Papers - 17/10/2022 - by Dongyue Yu, Frederick Fiddler, Ahmed Ibrahim, Raymond Sanedrin, Heidi Tremblay, Stephen W. Hoag
    The amorphous solid dispersion (ASD) is a widely adopted strategy for improving the dissolution of drugs with poor aqueous solubility. However, the selection of an appropriate polymer and drug loading …
    Hydrochlorothiazide/Losartan Potassium Tablet Prepared by Direct Compression

    Hydrochlorothiazide/losartan potassium tablet prepared by direct compression

    Papers - 21/08/2022 - by Luo Qiuhua, Zhang Qianying, Wang Puxiu
    Hydrochlorothiazide (HCTZ)/losartan potassium (LOS-K) served as a model drug for the preparation of compound tablets. The investigation focused on the compression and mechanical properties of mixed powders to identify formulation …
    A new validation methodology for in silico tools based on X-ray computed tomography images of tablets and a performance analysis of one tool

    A new validation methodology for in silico tools based on X-ray computed tomography images of tablets and a performance analysis of one tool

    Papers - 16/09/2021 - by Sebastian Bollmann, Peter Kleinebudde
    The validation of in silico tools predicting the dissolution of pharmaceutical dosage forms through virtual matrices can be accomplished using X-ray micro-computed tomography images of actual pharmaceutical formulations. In this …
    Immediate-release formulations produced via twin-screw melt granulation: systematic evaluation of the addition of disintegrants

    Immediate-release formulations produced via twin-screw melt granulation: systematic evaluation of the addition of disintegrants

    Papers - 16/06/2021 - by Kristina E. Steffens, Karl G. Wagner
    The present study investigated the impact of the location and quantity of various superdisintegrants on the characteristics of tablets produced through twin-screw melt granulation (TSMG). Sodium-croscarmellose (CCS), crospovidone (CPV), and …
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    Recent development and complex tablet formulation design for versatile applications

    Bulletins - 31/07/2020 - by Aline Moulin, Mathieu Degomme
    In this article, Mathieu Degomme, PharmD, Pharmaceutical Development Project Manager, and Aline Moulin, PhD, Pharmaceutical Development Director, both of Skyepharma, outline three case studies from recent early-stage development programmes to …
    Biopharmaceutical implications of excipient variability on drug dissolution from immediate release products

    Biopharmaceutical implications of excipient variability on drug dissolution from immediate release products

    Papers - 16/07/2020 - by P. Zarmpi, T. Flanagan, E. Meehan, J. Mann, J. Østergaard, N. Fotaki
    Examining the influence of excipient variability on oral product performance from a biopharmaceutical perspective could be advantageous and facilitate the integration of excipients into Quality by Design (QbD) approaches. The …
    Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering

    Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering

    Papers - 01/01/2020 - by Leonie Wagner-Hattler, Gabriela Québatte, Jennifer Keiser, Joachim Schoelkopf, Christian M. Schlepütz, Jörg Huwyler, Maxim Puchkov
    Ensuring uniform drug distribution within rapidly disintegrating tablets is a critical quality criterion for achieving a consistent, controlled, and targeted release of the active pharmaceutical ingredients they contain. This study …
    Manufacturing of multi-drug formulations with customised dose by solvent impregnation of mesoporous silica tablets

    Manufacturing of multi-drug formulations with customised dose by solvent impregnation of mesoporous silica tablets

    Papers - 01/01/2019 - by Marek Šoltys, Sarah Akhlasová, Aleš Zadražil, Pavel Kovačík, František Štěpánek
    The production of personalized medicines, where specific combinations of active pharmaceutical ingredients (APIs) and their doses within a tablet are adjusted to individual patient needs, necessitates novel manufacturing approaches compared …
    Evaluating scale-up rules of a high-shear wet granulation process

    Evaluating scale-up rules of a high-shear wet granulation process

    Papers - 01/07/2015 - by Jing Tao, Preetanshu Pandey, Dilbir S. Bindra, Julia Z. Gao, Ajit S. Narang
    This study aimed to assess the applicability of commonly employed scale-up rules for the high-shear wet granulation process, utilizing a formulation with low drug loading based on microcrystalline cellulose-lactose. Various …