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    STYL'One Evo scientist

    STYL’One Evo R&D – Scale-up and production support

    Newsfeeds - 10/07/2024 -
    The STYL’One Evo is a versatile, advanced R&D tablet press designed for use from early API characterization to production support. It is easy to use, clean, and maintain, featuring intuitive …
    Optimizing twin-screw melt granulation: The role of overflight clearance on granulation behavior

    Optimizing twin-screw melt granulation: The role of overflight clearance on granulation behavior

    Papers - 25/03/2024 - by Adwait Pradhan, Brian Phillips, Fengyuan Yang, Kapish Karan, Thomas Durig, Brian Haight, Charlie Martin, Feng Zhang
    Twin-screw melt granulation (TSMG) relies on both dispersive and distributive mixing at the kneading zone to facilitate granule growth, underscoring the pivotal role played by kneading elements in TSMG. Despite …
    Cocrystallization improves the tabletability of ligustrazine despite a reduction in plasticity

    Cocrystallization improves the tabletability of ligustrazine despite a reduction in plasticity

    Papers - 28/02/2024 - by Gerrit Vreeman, Danyingzi Guan, Yuncheng Cai, Qun Zhou, Changquan Calvin Sun
    Cocrystallization proves to be a potent technique for modifying the tableting performance of crystals by adjusting their mechanical attributes. This research delves into the cocrystallization of ligustrazine (LIG) with malonic …
    Comprehensive evaluation of polymer types and ratios in Spray-Dried Dispersions: Compaction, Dissolution, and physical stability

    Comprehensive evaluation of polymer types and ratios in Spray-Dried Dispersions: compaction, dissolution, and physical stability

    Papers - 25/01/2024 - by Dongyue Yu, Haichen Nie, Stephen W. Hoag
    The amorphous solid dispersion (ASD) method is a well-established approach to enhance the solubility and bioavailability of poorly soluble drugs. Although a significant number of ASD products are in tablet …
    Development of direct compression Acetazolamide tablet with improved bioavailability in healthy human volunteers enabled by cocrystallization with p-Aminobenzoic acid

    Development of direct compression Acetazolamide tablet with improved bioavailability in healthy human volunteers enabled by cocrystallization with p-Aminobenzoic acid

    Papers - 07/01/2024 - by Nimmy Kumari, Parag Roy, Sukanta Roy, Chenguang Wang, Sourav Das, Noopur Pandey, Susanta Kumar Mondal, Anirbandeep Bose, Changquan Calvin Sun, Animesh Ghosh
    Pharmaceutical cocrystallization is widely applied to enhance the physicochemical attributes of Active Pharmaceutical Ingredients (APIs). However, the formulation of cocrystals with demonstrated clinical success is currently limited. The successful translation …
    Effect of particle size on the dispersion behavior of magnesium stearate blended with microcrystalline cellulose

    Effect of particle size on the dispersion behavior of magnesium stearate blended with microcrystalline cellulose

    Papers - 07/01/2024 - by Daniel Puckhaber, Jan Henrik Finke, Sarah David, Bindhumadhavan Gururajan, Supriya Rane, Arno Kwade
    Most tablets produced include lubricants to minimize friction during ejection. However, in the case of plastically deforming materials such as microcrystalline cellulose (MCC), internal incorporation of lubricants is known to …
    Elucidating the effect of salt incorporation in tablets on tablet disintegratability

    Elucidating the effect of salt incorporation in tablets on tablet disintegratability

    Papers - 04/01/2024 - by Audrey Yi Zheng, Yuan Wei Liau, Paul Wan Sia Heng, Lai Wah Chan
    The breakdown of tablets is vital for promoting drug release, and disintegrants are utilized in tablet formulations to enhance this process. This study aimed to investigate the influence of incorporating …
    Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine

    Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine

    Papers - 27/11/2023 - by Dario A. Dornbierer, Laurenz Marten, Jovin Mueller, Helena D. Aicher, Michael J. Mueller, Martina Boxler, Michael Kometer, Davor Kosanic, Robin Von Rotz, Maxim Puchkov, Thomas Kraemer, Hans-Peter Landolt, Erich Seifritz, Milan Scheidegger
    Recently, the plant medicine "ayahuasca" from the Amazon, which contains the psychedelic compound N,N-dimethyltryptamine (DMT) and various β-carboline alkaloids like harmine, has been proposed as having positive effects in individuals …
    Sticking Detection by Repeated Compactions on a Single Tablet

    Sticking detection by repeated compactions on a single tablet

    Papers - 21/11/2023 - by James Thomas, Phuong Bui, Antonios Zavaliangos
    Tablet sticking in the context of tablet manufacturing refers to the buildup of tablet material on the punch after multiple compaction cycles. The occurrence of sticking can impact tablet weight, …
    Developmental strategy for swellable/erodible matrix tablet of mirabegron: quality by design approach with various geometric properties and pharmacokinetic evaluation

    Developmental strategy for swellable/erodible matrix tablet of mirabegron: quality by design approach with various geometric properties and pharmacokinetic evaluation

    Papers - 21/11/2023 - by Ji Yeon Kim, Tae Hwan Kim, Eunbin Kim, Du Hyung Choi
    Objective: This study aimed to devise a developmental strategy for matrix tablets containing mirabegron, incorporating a quality by design approach that considers geometric properties such as gel strength, erosion rate, …
    Tableting properties of freeze-dried trehalose: physico-chemical and mechanical investigation

    Tableting properties of freeze-dried trehalose: physico-chemical and mechanical investigation

    Papers - 11/11/2023 - by Hassana Hsein, Charbel Madi, Vincent Mazel, Pierre Tchoreloff, Virginie Busignies
    The preferred method for enhancing the stability and storage conditions of biopharmaceutical products is freeze-drying. Typically, these freeze-dried products are designed for administration via the parenteral route. However, many parenterally …
    Examining the effect of spatial distribution of disintegrant particles on tablet disintegratability

    Examining the effect of spatial distribution of disintegrant particles on tablet disintegratability

    Papers - 09/11/2023 - by Audrey Yi Zheng, Wei Wei Huang, Li Ying Jolene Poon, Eunice Siying Wong, Paul Wan Sia Heng, Lai Wah Chan
    Objective Typically employed at low concentrations in tablets, superdisintegrants may exhibit an uneven spatial distribution within the tablet, leading to varied disintegration times. This study aimed to explore the impact …
    Enhancement of material attributes of poorly compressible metformin hydrochloride through coprocessing with hydroxypropyl cellulose (HPC-L) using coprecipitation (CPT)

    Enhancement of material attributes of poorly compressible metformin hydrochloride through coprocessing with hydroxypropyl cellulose (HPC-L) using coprecipitation (CPT)

    Papers - 06/11/2023 - by Kaushalendra Chaturvedi, Pasaorn Pongkulapa, Xiaoyi Ding, Harsh S. Shah, San Kiang, Veeran Kadajji
    Coprocessing entails integrating multiple substances to enhance the physical, chemical, mechanical, and biopharmaceutical properties of a material. It stands as a promising technique in the pharmaceutical industry, supporting both drug …
    Investigating the effect of sintering rate and solvent type on the liquid transport kinetics of α-alumina powder compacts

    Investigating the effect of sintering rate and solvent type on the liquid transport kinetics of α-alumina powder compacts

    Papers - 23/10/2023 - by Mohammed Al-Sharabi, Daniel Markl, Vincenzino Vivacqua, Prince Bawuah, Natalie MacLean, Andrew P.E. York, J. Axel Zeitler
    The transport of liquids into ceramic catalytic materials is influenced by both the properties of ceramic materials and the penetrating liquid. Terahertz pulsed imaging (TPI), coupled with a flow cell, …
    Comparing failure tests on pharmaceutical tablets: Interpretation using experimental results and a numerical approach with cohesive zone models

    Comparing failure tests on pharmaceutical tablets: Interpretation using experimental results and a numerical approach with cohesive zone models

    Papers - 25/07/2023 - by Vincent Mazel, Jérémie Girardot, Jean-Benoit Kopp, Stéphane Morel, Pierre Tchoreloff
    The mechanical strength is an important quality attribute of pharmaceutical tablets. It can be determined using different failure tests like the Brazilian test or the three-point bending test. Nevertheless, literature …
    Comparison of scale-up strategies in twin-screw wet granulation

    Comparison of scale-up strategies in twin-screw wet granulation

    Papers - 25/06/2023 - by Marcel Franke, Thomas Riedel, Robin Meier, Carsten Schmidt, Peter Kleinebudde
    This study aimed to evaluate different scale-up strategies in twin-screw wet granulation and assess their impact on granule and tablet properties for a specific formulation. The granulation process was transitioned …
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    Structural and functional analysis of a new co-processed tableting excipient for food compaction processes

    Papers - 20/06/2023 - by René Rösemeier-Scheumann, Lars Wagner, Ulrich Bobe, Annabel Bozon, Arno Kwade, Jan Henrik Finke
    Food compacts offer convenience to both the industry and customers, necessitating a robust strength to endure the rigors of packaging processes and customer handling. Unlike pharmaceutical applications, where excipient choices …
    Investigating compressibility descriptors for binary mixtures of different deformation behavior

    Investigating compressibility descriptors for binary mixtures of different deformation behavior

    Papers - 15/06/2023 - by Sabrina Berkenkemper, Stefan Klinken, Peter Kleinebudde
    Tablets remain one of the most crucial dosage forms, and a key objective in the development of these forms is predicting their tableting behavior. The endeavor to save resources and …
    Bioaccumulated provitamin A in black soldier fly larvae is bioavailable and capable of improving vitamin A status of gerbils

    Bioaccumulated provitamin A in black soldier fly larvae is bioavailable and capable of improving vitamin A status of gerbils

    Papers - 08/06/2023 - by Lisa Morand-Laffargue, Stéphane Delbecq, Benjamin Creton, Damien Sabatier, Marie Papin, Claudie Dhuique-Mayer, Patrick Borel
    The objective of the study was to investigate the bioavailability of provitamin A (proVA), which can accumulate in black soldier fly larvae (BSFL), and its potential to restore vitamin A …
    Process and formulation parameters influencing the survival of Saccharomyces cerevisiae during spray drying and tableting

    Process and formulation parameters influencing the survival of Saccharomyces cerevisiae during spray drying and tableting

    Papers - 05/06/2023 - by Karl Vorländer, Paula Pramann, Arno Kwade, Jan Henrik Finke, Ingo Kampen
    Probiotic microorganisms offer health benefits when administered in a viable form and at adequate doses. Dry dosage forms, particularly tablets, are preferred due to their numerous advantages. However, it is …