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    Air entrapment during tablet compression – diagnosis and impact on tableting performance assessed with a compaction simulator

    Air entrapment during tablet compression – diagnosis and impact on tableting performance assessed with a compaction simulator

    Papers - 02/11/2022 - by Gerrit Vreeman, Changquan Calvin Sun
    The occurrence of air entrapment during tablet compression has the potential to result in noteworthy defects in the tablets. Materials characterized by high plasticity and low bulk density are particularly …
    Using twin-screw melt granulation to co-process mannitol and hydroxypropylcellulose

    Using twin-screw melt granulation to co-process mannitol and hydroxypropylcellulose

    Papers - 01/11/2022 - by Adwait Pradhan, Mark Costello, Fengyuan Yang, Vivian Bi, Thomas Durig, Feng Zhang
    With the emergence of continuous manufacturing, there has been a growing interest in the pharmaceutical industry regarding twin-screw melt granulation as a technique for co-processing excipients and developing innovative formulations. …
    Improving the Manufacturability of Cohesive and Poorly Compactable API for Direct Compression of Mini-tablets at High Drug Loading via Particle Engineering

    Improving the manufacturability of cohesive and poorly compactable API for direct compression of mini-tablets at high drug loading via particle engineering

    Papers - 01/11/2022 - by Liang Chen, Yiqing Lin, Erwin Irdam, Nicole Madden, Frederick Osei-Yeboah
    The aim is to employ a particle engineering approach to enhance the manufacturability of a cohesive and challenging-to-compact active pharmaceutical ingredient (API) with a high drug loading, specifically for the …
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    A powder tabletability equation

    Papers - 01/11/2022 -
    A mathematical expression delineating the relationship between the tensile strength of tablets and compaction pressure was formulated using the equations initially suggested by Ryshkewitch and Kuentz-Leuenberger. This equation was applied …
    Surface Characterization as a Tool for Identifying the Factors Affecting the Dissolution Rate of Amorphous Solid Dispersion Tablets

    Surface characterization as a tool for identifying the factors affecting the dissolution rate of amorphous solid dispersion tablets

    Papers - 17/10/2022 - by Dongyue Yu, Frederick Fiddler, Ahmed Ibrahim, Raymond Sanedrin, Heidi Tremblay, Stephen W. Hoag
    The amorphous solid dispersion (ASD) is a widely adopted strategy for improving the dissolution of drugs with poor aqueous solubility. However, the selection of an appropriate polymer and drug loading …
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    Understanding the multidimensional effects of polymorphism, particle size and processing for D-Mannitol powders

    Papers - 07/10/2022 - by Lena Mareczek, Carolin Riehl, Meike Harms, Stephan Reichl
    This study investigated the influence of polymorphic form, particle size, and processing of mannitol on the mechanical properties of solid oral dosage forms. The particle and powder properties of spray …
    Tableting Performance of Maize and Potato Starches Used in Combination as Binder/Disintegrant in Metronidazole Tablet Formulation

    Tableting performance of maize and potato starches used in combination as binder/disintegrant in Metronidazole tablet formulation

    Papers - 01/10/2022 - by Yonni Eshovo Apeji, Rejoice Thomas Kaigama, Sani Hadi Ibrahim, Sophie Nock Anyebe, Aisha Ohunene Abdussalam, Avosuahi Rukayat Oyi
    The objective of this study was to evaluate the tableting characteristics of maize and potato starches when employed either as disintegrants or binders in the development of solid dosage forms. …
    Development of a multiparticulate drug delivery system for in situ amorphisation

    Development of a multiparticulate drug delivery system for in situ amorphisation

    Papers - 01/10/2022 - by Tobias Palle Holm, Marcel Kokott, Matthias Manne Knopp, Ben J. Boyd, Ragna Berthelsen, Julian Quodbach, Korbinian Löbmann
    In this study, the application of multiparticulate drug delivery systems (MDDS) was explored for tablets designed to amorphize supersaturated granular amorphous solid dispersions (ASDs) in situ—specifically, achieving amorphization through microwave …
    Tablets Made from Paper - An Industrially Feasible Approach

    Tablets made from paper - An industrially feasible approach

    Papers - 27/09/2022 - by Ayat Abdelkader, Christoph Moos, Adrien Pelloux, Marcus Pfeiffer, Christian Alter, Stefan Kolling, Cornelia Keck
    Numerous orally administered drugs face challenges in bioavailability due to limited solubility. The smartFilm technology presents an innovative solution for enhancing drug aqueous solubility by incorporating the drug into the …
    Studies on the influence of high-shear granulation process on the compressibility of microcrystalline cellulose

    Studies on the influence of high-shear granulation process on the compressibility of microcrystalline cellulose

    Papers - 25/09/2022 - by Boyun Xiao, Jiaqi Zhang, Lixin Geng, Xing Tang, Yanjiao Wang, Tian Yin, Yu Zhang, Jingxin Gou, Haibing He
    Microcrystalline cellulose (MCC) serves as a diluent in the formulation of oral solid dosage forms. In this predictive study, the wet granulation process was chosen to produce tablets containing losartan …
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    Varied bulk powder properties of micro-sized API within size specifications as a result of particle engineering methods

    Papers - 08/09/2022 - by Zijian Wang, Marina Solomos, Stephanus Axnanda, Chienhung Chen, Margaret Figus, Luke Schenck, Changquan Calvin Sun
    Micronized particles are commonly employed to enhance content uniformity (CU), dissolution performance, and the bioavailability of active pharmaceutical ingredients (API). Various particle engineering methods have been developed to produce micron-sized …
    Impact of Lubrication on Key Properties of Orodispersible Minitablets in Comparison to Conventionally Sized Orodispersible Tablets

    Impact of lubrication on key properties of orodispersible minitablets in comparison to conventionally sized orodispersible tablets

    Papers - 05/09/2022 - by Jennifer Kuck, Jörg Breitkreutz
    Orodispersible minitablets (ODMTs) offer several advantages such as ease of swallowability, dose flexibility, and straightforward manufacturing through direct compression. This study investigates the impact of lubrication on five different co-processed …
    Compressibility analysis as robust in-die compression analysis for describing tableting behaviour

    Compressibility analysis as robust in-die compression analysis for describing tableting behaviour

    Papers - 01/09/2022 - by Sabrina Berkenkemper, Peter Kleinebudde
    Objectives: The compressibility of materials plays a crucial role in determining the tableting behavior and tablet properties throughout and after the manufacturing process. In this study, we explored the compressibility …
    The effect of granules characters on mechanical properties of press-coated tablets: A comparative study

    The effect of granules characters on mechanical properties of press-coated tablets: A comparative study

    Papers - 25/08/2022 - by Peifu Xiao, Yibin Guo, Jiahui Wang, Hongbing Liu, JiaXin Zhang, YanJiao Wang, Tian Yin, Yu Zhang, Jingxin Gou, Haibing He, Xing Tang
    The objective of this study was to examine the relationship between crucial granule characteristics (including particle size, surface roughness, and apparent porosity) and the mechanical properties of press-coated tablets. Granules …
    The Overview of Oral Solid Dosage Forms and Different Excipients Used for Solid Dosage Formulation

    The overview of oral solid dosage forms and different excipients used for solid dosage formulation

    Papers - 24/08/2022 - by Ms. Kiran Rameshbhai Dudhat
    In the development of pharmaceutical dosage forms, the choice of excipients plays a pivotal role in both preformulation and formulation research. The physical, mechanical, and chemical attributes of excipients exert …
    Hydrochlorothiazide/Losartan Potassium Tablet Prepared by Direct Compression

    Hydrochlorothiazide/losartan potassium tablet prepared by direct compression

    Papers - 21/08/2022 - by Luo Qiuhua, Zhang Qianying, Wang Puxiu
    Hydrochlorothiazide (HCTZ)/losartan potassium (LOS-K) served as a model drug for the preparation of compound tablets. The investigation focused on the compression and mechanical properties of mixed powders to identify formulation …
    Influence of the drug deformation behaviour on the predictability of compressibility and compactibility of binary mixtures

    Influence of the drug deformation behaviour on the predictability of compressibility and compactibility of binary mixtures

    Papers - 17/08/2022 - by Isabell Wünsch, Jan Henrik Finke, Edgar John, Michael Juhnke, Arno Kwade
    Numerous studies have sought to understand the predictability of compressibility and compactibility in tablet formulations by examining the behavior of individual materials. However, the complexity of the powder compaction process …
    A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants

    A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants

    Papers - 07/08/2022 - by Maarten Jaspers, Timo P. Roelofs, Pauline H.M. Janssen, Robin Meier, Bastiaan H.J. Dickhoff
    Roller compaction for dry granulation is gaining popularity as a method for producing oral solid dosage forms. The process offers simplicity compared to wet granulation and operates inherently in a …
    Charge reduction assisted production of diminutive fluid bed granules for high drug load minitablets

    Charge reduction assisted production of diminutive fluid bed granules for high drug load minitablets

    Papers - 25/07/2022 - by Shang Jun Loo, Paul Wan Sia Heng, Lai Wah Chan
    Micronized drug powders are often impractical for use as tableting feed to create minitablets due to their cohesiveness and poor flow properties. The addition of fumed silica (fSi) within an …
    Influence of the punch shape on the core and shell structure of press-coated tablets

    Influence of the punch shape on the core and shell structure of press-coated tablets

    Papers - 25/07/2022 - by Léo Picart, Vincent Mazel, Aline Moulin, Vanessa Bourgeaux, Pierre Tchoreloff
    Press-coated tablets play a pivotal role in achieving delayed releases in chronotherapeutics, with their drug release properties intricately tied to their distinctive core-shell structure. Therefore, understanding the impact of process …