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Compaction of recrystallised ibuprofen

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Ibuprofen (α-methyl-4-(isobutyl)phenylacetic acid) underwent recrystallization from various solvents, and the resulting samples were subjected to evaluation for particle morphology, crystallinity, melting points, and powder flow properties. Furthermore, the compaction properties of both the control ibuprofen and the recrystallized samples were analyzed at different compaction forces and speeds. This assessment was conducted both before and after blending with an equal amount of lactose using a Stylcam® 100R rotary press simulator. The recrystallized ibuprofen samples exhibited tablet strength equal to or better than the control. Notably, ibuprofen recrystallized from acetone demonstrated improved flowability, and ibuprofen recrystallized from 2-ethoxyethyl acetate showed reduced levels of elastic energy during compaction. Additionally, when formulated with lactose, the recrystallized ibuprofen samples displayed lower punch adhesion levels, particularly at lower compaction forces.
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