Formation of Delta-Mannitol bu co-spray drying to enhance tabletability of paracetamol-mannitol formulations

May 12, 2021, midnight - by E De Pauw , C Vervaet , V Vanhoorne

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Introduction: Mannitol (MAN) serves as a polymorphic excipient (α-, β-, δ-MAN) frequently utilized in tablet formulations. Although delta-mannitol (δ-MAN) exhibits superior compaction behavior, achieving consistent and scalable production poses a challenge. Paracetamol (PCM), a widely used analgesic and antipyretic, presents difficulties in tabletting within high-dose formulations due to capping. Objectives: Enhance the compressibility and tabletability of paracetamol-mannitol (PCM-MAN) formulations through the generation of δ-MAN via co-spray drying.