Influence of layer composition and compaction parameters on the manufacturing of sucralfate/ibuprofen lysine bi-layer tablets

May 4, 2016, midnight - by Alessandra Rossi , Matteo Molinari , Fabiola Lombardi , Luca Castrati , Dimitrios Rekkas , Stavros Politis , Ruggero Bettini , Paolo Colombo

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Investigation into the impact of layer composition and compaction parameters on the tendency of delamination in bi-layer tablets designed for the immediate release of two combined drugs. The initial layer comprised sucralfate, serving as a gastric mucosa protector, while the second layer contained ibuprofen lysine, an anti-inflammatory drug.