One strategy to address both solubility enhancement and controlled release: polyvinyl alcohol for hot melt extrusion

Jan. 1, 2017, midnight - by Guenter Moddelmog , Mengyao Zheng , Finn Bauer , Gudrun Birk , Dieter Lubda

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Tablets were formed from four distinct metal–organic framework powders (UiO-66, UiO-66-NH2, UiO-67, and HKUST-1). This study presents the impact of applied pressure on porous properties, mechanical strength, and tablet bulk density. A linear correlation between densification and tensile strength is noted for all four MOFs, with the slope varying depending on the specific MOF. Additionally, conditions that substantially enhance volumetric uptake are identified. Lastly, the stability of the tablets over time in the presence of moisture was assessed.