Simulations of drug release profiles as a function of different geometrical designs

Jan. 1, 2015, midnight - by Leonie Hattler , Jörg Huwyler , Maxim Puchkov

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INTRODUCTION: In combination therapy, ensuring release modifications for various compounds is crucial to align with individual medication's therapeutic objectives. The challenges in developing combination drugs stem not only from physicochemical properties but also from the intricate interplay of simultaneous drug releases from diverse geometries. Consequently, it necessitates thorough optimization and development. Therefore, a computer-based modeling approach capable of simulating release profiles for multiple drugs with distinct physicochemical properties becomes highly significant. The ability to model the geometries and arrangements of different drugs within various structures enables the optimization and enhancement of therapeutic effects. AIMS: Investigate simulated release profiles from complex geometries using a discrete element calculation method based on three-dimensional cellular automata.