Close search
Scientific papers

Scientific papers

Favorite Articles

    Tags

    Categories

    Authors

    79 results
    Date
    Characterization of the viscoelasticity of pharmaceutical tablets using impulse excitation technique

    Characterization of the viscoelasticity of pharmaceutical tablets using impulse excitation technique

    Papers - 05/02/2022 - by J. Meynard, F. Amado-Becker, P. Tchoreloff, V. Mazel
    The production of pharmaceutical tablets involves different types of presses, each with distinct compaction kinematics. Consequently, the strain rate sensitivity (SRS) of the powders used becomes a crucial property in …
    Insight into tableted pellets by combining X-ray micro-computed tomography and experimental compaction

    Insight into tableted pellets by combining X-ray micro-computed tomography and experimental compaction

    Papers - 20/12/2021 - by Imen Boudina, Eric Rondet, Saeid Nezamabadi, Tahmer Sharkawi
    Pellets, spherical agglomerated particles utilized in the production of multiparticulate pharmaceutical dosage forms, were the subject of this study aiming to introduce a novel approach for evaluating pellet deformation under …
    Stress transmission coefficient is a reliable and robust parameter for quantifying powder plasticity

    Stress transmission coefficient is a reliable and robust parameter for quantifying powder plasticity

    Papers - 09/12/2021 - by Gerrit Vreeman, Changquan Calvin Sun
    Existing methods for determining powder plasticity parameters are susceptible to errors in porosity measurements, which stem from inaccuracies in measuring compact density, true density, or both. This study utilized various …
    Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter

    Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter

    Papers - 01/12/2021 - by Gerrit Vreeman, Changquan Calvin Sun
    Despite the ability to characterize the plasticity of powders in a material-sparing and expedited manner, the indie Heckel analysis has been widely criticized for its sensitivity to several factors, such …
    Characterization of tableting speed-dependent deformation properties of active pharmaceutical ingredients in powder mixtures using uut-of-die method

    Characterization of tableting speed-dependent deformation properties of active pharmaceutical ingredients in powder mixtures using uut-of-die method

    Papers - 01/12/2021 - by Daisuke Mizunaga, Mika Koseki, Naoki Kamemoto, Satoru Watano
    This study investigated a quantitative evaluation method to assess the impact of tableting speed on the compression properties of pharmaceutical powders. Cilostazol and ibuprofen served as active pharmaceutical ingredients (APIs), …
    Lamination of pharmaceutical tablets: classification and influence of process parameters

    Lamination of pharmaceutical tablets: classification and influence of process parameters

    Papers - 23/10/2021 - by V. Mazel, P. Tchoreloff
    The occurrence of lamination is a prevalent issue in the pharmaceutical tablet manufacturing process, representing a failure of the tablet along one or more planes parallel to the surface and …
    Use of impulse excitation technique for the characterization of the elastic anisotropy of pharmaceutical tablets

    Use of impulse excitation technique for the characterization of the elastic anisotropy of pharmaceutical tablets

    Papers - 10/08/2021 - by J. Meynard, F. Amado-Becker, P. Tchoreloff, V. Mazel
    Capping and lamination are common defects encountered in the pharmaceutical tablet manufacturing process. Numerous studies have indicated that tablet anisotropy can contribute to the occurrence of such defects. This study …
    no-image

    Material characterization with a V-shape compression profile on STYL'One Nano

    Bulletins - 01/08/2021 - by Sixtine Caquant, Quentin Boulay
    In the early stages of drug development, APIs are often available in limited amount. However, scientists have to foresee the impact of compaction parameters on tablet attributes. In fact, tablet …
    no-image

    Material characterization with extended dwell time compression profile on STYL'One Nano

    Bulletins - 01/05/2021 - by Quentin Boulay, Sixtine Caquant
    During the development of a new drug, active materials are often available in small quantities for cost or process reasons. However, scientists have to understand their deformation behavior to design …
    Effect of the compaction parameters on the final structure and properties of a press-coated tablet (Tab-in-Tab): Experimental and numerical study of the influence of core and shell dimensions

    Effect of the compaction parameters on the final structure and properties of a press-coated tablet (Tab-in-Tab): Experimental and numerical study of the influence of core and shell dimensions

    Papers - 01/03/2021 - by Léo Picart, Vincent Mazel, Aline Moulin, Pierre Tchoreloff
    With the growing interest in chronopharmaceutics, press-coated tablets have emerged as a pivotal technology in the realm of modified release drug delivery systems. While considerable research has explored their advantages …
    Effect of excipient particle size distribution variability on compact tensile strength; and its in-line prediction by force-displacement and force-time profiling

    Effect of excipient particle size distribution variability on compact tensile strength; and its in-line prediction by force-displacement and force-time profiling

    Papers - 12/01/2021 - by Wee Beng Lee, Effendi Widjaja, Paul Wan Sia Heng, Lai Wah Chan
    Background: The sensitivity of direct compression to the variability in particle size distribution (PSD) of pharmaceutical-grade excipients remains insufficiently explored. Additionally, the utilization of a force sensor as a process …
    The effects of spray drying, HPMCAS grade, and compression speed on the compaction properties of itraconazole-HPMCAS spray dried dispersions

    The effects of spray drying, HPMCAS grade, and compression speed on the compaction properties of itraconazole-HPMCAS spray dried dispersions

    Papers - 16/09/2020 - by Moshe Honick, Sharmila Das, Stephen W. Hoag, Francis X. Muller, Alaadin Alayoubi, Xin Feng, Ahmed Zidan, Muhammad Ashraf, James E. Polli
    Spray-dried dispersions (SDDs) hold considerable potential in enhancing the oral bioavailability of drugs with limited water solubility. Nevertheless, SDDs often exhibit material attributes, such as small particle size, low bulk …
    Applicability of impulse excitation technique as a tool to characterize the elastic properties of pharmaceutical tablets: Experimental and numerical study

    Applicability of impulse excitation technique as a tool to characterize the elastic properties of pharmaceutical tablets: Experimental and numerical study

    Papers - 16/09/2020 - by Vincent Mazel, Pierre Tchoreloff
    Elastic properties play a crucial role in tablet development, particularly in formulating the composition and defining process parameters. This article introduces impulse excitation as an innovative, rapid, and cost-effective technology …
    Characterization and modeling of the viscoelasticity of pharmaceutical tablets

    Characterization and modeling of the viscoelasticity of pharmaceutical tablets

    Papers - 28/07/2020 - by Léo Desbois, Pierre Tchoreloff, Vincent Mazel
    The variation in compaction properties of powders with compaction speed, known as strain rate sensitivity (SRS), is a common occurrence in the pharmaceutical tablet manufacturing process. However, various phenomena, such …
    High-molecular-weight hypromellose from three different suppliers: effects of compression speed, tableting equipment, and moisture on the compaction

    High-molecular-weight hypromellose from three different suppliers: effects of compression speed, tableting equipment, and moisture on the compaction

    Papers - 01/07/2020 - by Peter Grdešič, Amrit Paudel, Ilija German Ilić
    The increasing significance of higher tableting speeds in the pharmaceutical industry prompts a need for comprehensive studies on the mechanical properties of hypromellose. Surprisingly, there is a lack of recent …
    Cushioning pellets based on microcrystalline cellulose – Crospovidone blends for MUPS tableting

    Cushioning pellets based on microcrystalline cellulose – Crospovidone blends for MUPS tableting

    Papers - 26/06/2020 - by Ramy N. Elsergany, Lai Wah Chan, Paul Wan Sia Heng
    Compacting tablets within a multiple-unit pellet system (MUPS) has been widely acknowledged as potentially challenging. Consequently, there is a growing demand for non-segregating cushioning agents to alleviate the adverse effects …
    no-image

    Cushioning pellets based on microcrystalline cellulose – Crospovidone blends for MUPS tableting

    Papers - 26/06/2020 - by Ramy N. Elsergany, Lai Wah Chan, Paul Wan Sia Heng
    Compaction of multiple-unit pellet system (MUPS) tablets has been extensively reported to be potentially challenging. Thus, there is a need for non-segregating cushioning agents to mitigate the deleterious effect of …
    Compression of vectors for small interfering RNAs delivery: toward oral administration of siRNA lipoplexes in tablet forms

    Compression of vectors for small interfering RNAs delivery: toward oral administration of siRNA lipoplexes in tablet forms

    Papers - 06/04/2020 - by Virginie Busignies, Danielle Campiol Arruda, Christine Charrueau, Marcela Coelho Silva Ribeiro, Anne-Marie Lachagès, Angelo Malachias, Stéphanie Finet, Asad Ur Rehman, Pascal Bigey, Pierre Tchoreloff, Virginie Escriou
    Presently, the majority of nonviral nucleic acid vectors are formulated as colloidal suspensions primarily administered parenterally. This formulation and administration method impose significant constraints, such as vector size limitations and …
    Effect of particle size on powder compaction and tablet strength using limestone

    Effect of particle size on powder compaction and tablet strength using limestone

    Papers - 01/03/2020 - by Ramon Cabiscol, Hao Shi, Isabell Wünsch, Vanessa Magnanimo, Jan Henrik Finke, Stefan Luding, Arno Kwade
    The compaction of powders at high loads poses a challenge due to the simultaneous occurrence of particle rearrangement, compression, and breakage. Although tableting is a pivotal process in pharmaceutical technology, …
    Systematic approach to elucidate compaction behavior of acyclovir using a compaction simulator

    Systematic approach to elucidate compaction behavior of acyclovir using a compaction simulator

    Papers - 01/02/2020 - by Cheol-Hee Cho, Ju-Young Kim, Eun-Seok Park
    In this study, various methodologies were employed using a compaction simulator to explore the compaction behavior of acyclovir, a model compound with unidentified characteristics. Multiple indicators were utilized to assess …