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    Systematic investigation of the impact of screw elements in continuous wet granulation

    Papers - 01/12/2024 - by Katharina Kiricenko, Robin Meier, Peter Kleinebudde
    Twin-screw wet granulation (TSG) is a continuous manufacturing method used either to produce granules as a final dosage form or as an intermediate step before tablet or capsule production. Successfully …
    Partnership with knowledge gain - on both sides

    Partnership with knowledge gain – on both sides

    Newsfeeds - 26/11/2024 -
    The partnership between KORSCH, MEDELPHARM, and the Institute of Particle Technology (iPAT) at the Technical University of Braunschweig focuses on advancing tableting technologies and understanding powder behavior through collaborative research. …
    KORSCH XT 600 Pharma Networking

    KORSCH bringing to PMEC India tabletting solutions from R&D to high-speed production

    Newsfeeds - 25/11/2024 -
    KORSCH Highlights Innovation at PMEC India 2024Berlin-based tablet compression leader KORSCH AG will showcase its cutting-edge technologies at PMEC India 2024, held at the India Expo Centre, Greater Noida, under …
    tablet white

    A recipe for success: mastering tableting requires understanding ingredient attributes

    Newsfeeds - 12/09/2024 -
    The author discusses the importance of understanding ingredient attributes in the process of tablet manufacturing. It emphasizes that consistently producing high-quality tablets requires more than just creating a successful small-scale …
    I Holland tooling

    Saving time and money by selecting the correct anti-abrasive solution

    White Papers - 28/08/2024 -
    Thompson & Capper is a contract manufacturer of pharmaceutical and nutritional tablets, based in the UK. They produce over 2.5 billion tablets every year, mainly for clients in Europe.Thompson & …
    Image effect of glidant on tabletting behavior

    The effect of glidant on the tabletting behavior of common pharmaceutical excipients

    Newsfeeds - 09/08/2024 -
    The article on Pharma Excipients discusses the impact of glidants on the tabletting process in pharmaceutical manufacturing. Glidants are substances added to improve the flow properties of powders during tablet …
    Dwell Time on Tableting: Dwell Time According to Force versus Geometric Dwell Time

    Dwell time on tableting: dwell time according to force versus geometric dwell time

    Papers - 24/07/2024 - by Valentyn Mohylyuk
    Dwell time is a key parameter influencing the material deformation and the mechanical and biopharmaceutical properties of a tablet, making it essential for scale-up processes. Geometric dwell time (GDT) can …
    Image MEDELPHARM STYL'One Nano for early-stage characterization

    STYL’One Nano R&D compaction simulator for early-stage material characterization and development

    Newsfeeds - 13/06/2024 -
    The MEDELPHARM STYL’One Nano is a compact and advanced compaction simulator designed for early-stage tablet formulation in research and development. It helps researchers address formulation challenges in tablet and oral …
    KORSCH-XL4004-MFP

    KORSCH bringing world's most flexible tablet press to FCE Brazil expo

    Newsfeeds - 27/05/2024 -
    KORSCH AG, a leading tablet compression technology company, will showcase its advanced XL 400⁴ MFP Tablet Press at the FCE 2024 pharma industry expo in São Paulo, Brazil. TheXL 400⁴ …
    Image - Article I Holland GR lanes

    Working with GR Lanes Health Products Ltd.

    White Papers - 23/04/2024 -
    Lanes, is a leading UK family-owned pharmaceutical company that specialises in producing natural remedies and is famous for brands such as Olbas and Kalms. Market leading products like these demand …
    Take-off sensor as a tool for sticking assessment during tablet development

    Take-off sensor as a tool for sticking assessment during tablet development

    Papers - 21/03/2024 - by Adrien Pelloux, Delphine Ach-Hubert, Sixtine Caquant
    More than 70% of candidate drugs have low solubility (BCS Class II and IV) (Nikolakakis et al. 2017). Making tablets with low solid fraction improves the dissolution rate (Van der …
    Galenic laboratory Armor - video screen

    See the galenic laboratory at Armor Pharma

    Newsfeeds - 15/03/2024 -
    Since 2020, Armor Pharma has made significant investments in a cutting-edge galenic laboratory, enhancing their expertise as a leading pharmaceutical lactose provider.Check out the latest video showcasing Armor Pharma's State-of-the-art …
    The impact of diluents on the compaction, dissolution, and physical stability of amorphous solid dispersion tablets

    The impact of diluents on the compaction, dissolution, and physical stability of amorphous solid dispersion tablets

    Papers - 22/02/2024 - by Dongyue Yu, Stephen W. Hoag
    The amorphous solid dispersion (ASD) method proves effective in enhancing the solubility, dissolution, and bioavailability of poorly water-soluble medications. However, these forms are prone to transitioning into more thermodynamically stable, …
    Comprehensive evaluation of polymer types and ratios in Spray-Dried Dispersions: Compaction, Dissolution, and physical stability

    Comprehensive evaluation of polymer types and ratios in Spray-Dried Dispersions: compaction, dissolution, and physical stability

    Papers - 25/01/2024 - by Dongyue Yu, Haichen Nie, Stephen W. Hoag
    The amorphous solid dispersion (ASD) method is a well-established approach to enhance the solubility and bioavailability of poorly soluble drugs. Although a significant number of ASD products are in tablet …
    Effect of particle size on the dispersion behavior of magnesium stearate blended with microcrystalline cellulose

    Effect of particle size on the dispersion behavior of magnesium stearate blended with microcrystalline cellulose

    Papers - 07/01/2024 - by Daniel Puckhaber, Jan Henrik Finke, Sarah David, Bindhumadhavan Gururajan, Supriya Rane, Arno Kwade
    Most tablets produced include lubricants to minimize friction during ejection. However, in the case of plastically deforming materials such as microcrystalline cellulose (MCC), internal incorporation of lubricants is known to …
    Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

    Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

    Papers - 08/12/2023 - by Natalia Veronica, Yi Ying Loh, Lydia Xiu Ying Loh, Paul Wan Sia Heng, Celine Valeria Liew
    Thumbnail webinar replay Self-Driving Tableting DataFactory

    Self-driving tableting DataFactory

    Webinar Replays - 07/12/2023 - by Daniel Markl, Bruno Leclercq
    "Self-driving tableting DataFactory"- with guest speaker Daniel Markl, reader at the University of Strathclyde and Associate Director at the CMAC Center for Continuous Manufacturing and Advanced CrystallisationTraditional methods of developing …
    Extended Dwell Flat (XDF) tooling at IHolland

    Timing is key in tabletting

    White Papers - 29/11/2023 -
    Why you need to get your timing right to make better tabletsNeed to mass-produce tablets with quality solid dosage in a quick and cost-effective way? The time that a formulation …
    Tableting properties of freeze-dried trehalose: physico-chemical and mechanical investigation

    Tableting properties of freeze-dried trehalose: physico-chemical and mechanical investigation

    Papers - 11/11/2023 - by Hassana Hsein, Charbel Madi, Vincent Mazel, Pierre Tchoreloff, Virginie Busignies
    The preferred method for enhancing the stability and storage conditions of biopharmaceutical products is freeze-drying. Typically, these freeze-dried products are designed for administration via the parenteral route. However, many parenterally …
    no-image

    Effects of tableting process parameters and powder lubrication levels on tablet surface temperature and moisture content

    Papers - 08/11/2023 - by Komlan Koumbogle, Ryan Gosselin, François Gitzhofer, Nicolas Abatzoglou
    The occurrence of punch sticking poses a recurrent challenge in the pharmaceutical tablet manufacturing process. The moisture content of the powder plays a crucial role in the development of sticking; …