Scientific papers
Aqueous solvent-based tablet coating is a well-established, environmentally sustainable alternative to coatings with organic solvents. However, this approach necessitates careful assessment of potential quality concerns, such as increased porosity and crack formation, due to interactions between tablet components and water. This study investigates the compression behavior of quaternary mixtures comprising a model drug and three common excipients. Tablets were coated sequentially with a hypromellose aqueous solution and an enteric coating made from a poly(methyl acrylate-co-methyl methacrylate-co-methacrylic acid) dispersion. At each stage, tablet porosity was analyzed using X-Ray microcomputed tomography (XµCT). The analysis revealed significant structural changes in some tablets following coating, with porosity increases of up to 12%. The mechanical properties of the mixture components were found to play a critical role in these changes, as materials undergoing significant plastic densification during compression exhibited more pronounced swelling and cracking. XµCT proved to be an invaluable tool for detecting morphological alterations that could impact tablet quality.
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