Tableting of liquid form active ingredient with high performance liquid carrier

November 07, 2023

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The article discusses the use of FLORITE, a macro porous calcium silicate, as a practical alternative to liquid carriers for tableting formulations with liquid active ingredients.

Fish oil was utilized as a model material due to its instability. The study found that FLORITE demonstrated considerable liquid absorbency, resulting in the formation of stable fish oil powder at various mixing ratios.

Furthermore, stability tests indicated that FLORITE suppressed fish oil oxidation more effectively compared to silicon dioxide, likely due to its deep macro pores that shield the fish oil from the surrounding air.

Finally, when compressed into tablets with excipients, FLORITE tablets exhibited superior hardness and cleanliness compared to tablets made with silicon dioxide, demonstrating FLORITE's potential as a high-performance carrier for tableting liquid form active ingredients.