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    round-tablets-on-yellow-background-3683057

    PEARLITOL® 200 GT Mannitol: Harnessing the potential of higher active ingredient content for smaller, more convenient tablets

    Newsfeeds - 20/02/2024 -
    The article discusses the development and optimization of PEARLITOL® 200 GT, a new pure beta mannitol grade for direct compression in tablet manufacturing. Mannitol is commonly used as an excipient …
    Effect of geometrical features on the capping behavior of biconvex tablets

    Effect of geometrical features on the capping behavior of biconvex tablets

    Papers - 03/09/2023 - by Vincent Mazel, Cléo Garcia, Pierre Tchoreloff
    Capping is a prevalent issue in the pharmaceutical tablet manufacturing process, influenced by both process and formulation parameters. This study systematically examined the impact of the geometrical features of biconvex …
    ME-092-EN-A_Tableting_Rheology_and_Quality_by_D.original

    Tableting rheology and quality by design

    White Papers - 18/01/2023 -
    Quality by Design (QbD) in tablet development can be challenging, due to the multiple competing technological aims, such as flow, compactability, lubrication and drug release. Tablets are complex and, whether …
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    The Assessment of the Capping Tendency of the Tablet during The Pharmaceutical Tabletting Using Finite Element Analysis in Computational Modelling Tools

    Papers - 29/11/2022 - by Halahakoon Hmaj
    The pharmaceutical powder compression cycle involves multiple stages, each associated with intricate mechanisms such as particle rearrangement, densification, inter-particle interaction, friction, elastic and plastic deformation, and particle fragmentation. A comprehensive …
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    On the complexity of predicting tablet capping

    Papers - 23/06/2022 - by J. Meynard, F. Amado-Becker, P. Tchoreloff, V. Mazel
    Anticipating tablet defects, particularly capping, during the pharmaceutical manufacturing process poses a considerable challenge. The existing literature presents various parameters for predicting capping, yet a consensus has not been reached. …
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    Impact of unloading kinematics on the occurrence of capping during the production of pharmaceutical tablets

    Papers - 10/06/2022 - by J. Meynard, F. Amado-Becker, P. Tchoreloff, V. Mazel
    Capping, a common defect in pharmaceutical tablet manufacturing, has been associated with a decrease in the unloading speed during the manufacturing cycle, as indicated by several studies. Building on this …
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    Effect of Precompresion on Capping Tendency

    Bulletins - 06/04/2022 - by Sixtine Caquant
    Compaction simulators are a key technology allowing scientists to develop formulations and troubleshoot tablet defects. It means that formulation scientists or tech transfer engineers can assess the influence of process …
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    Troubleshooting tablet defects in no-time

    White Papers - 12/10/2021 - by Bruno Leclercq
    There are numerous tablet defects: chipping, picking & sticking, cracking, lamination & capping to name a few.Lamination & capping often occur during scale-up and are main issues in our industry. …
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    A fundamental step in your tablet development

    Bulletins - 01/09/2021 - by Adrien Pelloux
    Formulation development and technical transfer from lab to production can be challenging and requires a deep knowledge of your formulation. The integrated and intuitive data analysis features drive formulators and …
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    Enabling the direct compression of metformin hydrochloride through QESD crystallization

    Papers - 01/06/2021 - by Jerome Hansen, Peter Kleinebudde
    Metformin hydrochloride, employed in treating type 2 diabetes, exhibits notable challenges with poor flowability and agglomeration during storage, making direct compression into tablets a hitherto unsuccessful endeavor. A previous study …
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    Role of Precompression in the Mitigation of Capping: A Case Study

    Papers - 01/10/2020 - by Vincent Mazel, Pierre Tchoreloff
    Capping, a significant issue in pharmaceutical tablet manufacturing, involves the detachment of one of the tablet's convex portions during ejection from the press or after relaxation. Currently, solutions to this …
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    Quantification of tablet sensitivity to a stress concentration: Generalization of Hiestand's approach and link with the microstructure

    Papers - 01/06/2020 - by B. Croquelois, J. Girardot, J.B. Kopp, P. Tchoreloff, V. Mazel
    The sensitivity to stress concentration is a crucial factor in the development of pharmaceutical tablets, given its association with defects such as capping. Hiestand et al. introduced the Brittle Fracture …