Scientific papers
A strategy for optimizing precompression pressure, utilizing in-die elastic recovery, has been devised to effectively tackle tablet lamination caused by air entrapment. This approach involves intentionally intensifying the air entrapment problem through elevated tableting speeds and primary compaction pressures, while gathering data on in-die elastic recovery in relation to precompression pressure. The optimized precompression pressure, identified as yielding minimal elastic recovery, proves most successful in expelling air from the powder bed before main compression. With the application of this optimized precompression pressure, tablets made from a model blend prone to lamination due to air entrapment could be manufactured without issue across a broad spectrum of high main compaction pressures. Conversely, tablets lacking precompression immediately exhibited lamination upon ejection at equivalent main compaction pressures. This optimization method effectively addresses lamination problems stemming from air entrapment through precompression. A notable advantage of this strategy lies in its independence from the need for intact tablets to determine the optimized precompression pressure, as elastic recovery measurements are conducted in-die.
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