Scientific papers
Dwell time is a key parameter influencing the material deformation and the mechanical and biopharmaceutical properties of a tablet, making it essential for scale-up processes. Geometric dwell time (GDT) can be estimated from the shape of the punch head and the turret's diameter and speed. This study aims to compare dwell time recorded by a compaction simulator based on force (DTF) with the GDT calculated for a simulated rotary tablet press. The mixtures of microcrystalline cellulose and calcium phosphate (CEOLUSTM UF-711 and DI-CAFOS® A60) in varying proportions were used. Tablets were prepared, and DTF was analyzed with a compaction simulator (STYL’One Nano and Alix software) simulating a small rotary press at 70 rpm and a compression pressure of 10–50 kN (100-500 MPa). While GDT was 14.4 ms, DTF varied depending on compression force and formulation. Differences in DTF values between formulations decreased with increasing compression force, particularly noticeable at 10 and 15 kN.
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