Facilitating material-sparing dry granulation technical transfer through RoCo simulation of spray dried intermediate based formulations

June 4, 2024, midnight - by Allisson N. DuRoss , Kendall R. Pearson , Mark E. Waller , Hannah E. Worrest

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Problem Statement • Dry granulation (DG) demonstration batches consume large amounts of material and time • Spray dried intermediate (SDI) based tablets commonly require upstream dry granulation • Previous workflows removed reliance on rotary tablet demonstration batches via the STYL’One Evolution1 • DG is still required to • Determine settings for target attributes • Evaluate acceptable process ranges Can the STYL'One eliminate at-scale demo batches?

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