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Impact of functional-related characteristics (FRCs) of crospovidone on tablet disintegration performance

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Crospovidone, a commonly used superdisintegrant, is available in two pharmacopeial grades: Type A (with a coarser particle size) and Type B (with finer particles). Variations in particle size between these grades result in differences in functional related characteristics (FRCs), such as hydration capacity and powder flowability. This study aimed to assess the relative influence of these FRCs on tablet disintegration time. Multiple batches of both crospovidone grades were analyzed for particle size distribution, hydration capacity, and powder flow properties. Tablets were then formulated using these batches and tested for disintegration time. Correlation analyses were conducted to determine the independent effects of each FRC on disintegration behavior. Initial results indicated a strong interdependence between particle size, hydration capacity, and powder flowability. However, when particle size was isolated as the dominant variable, it was found that hydration capacity and flowability had minimal or no significant influence on disintegration time.
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Impact of functional-related characteristics (FRCs) of crospovidone on tablet disintegration performance
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