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    Image study - benefits of an optimal tabletability DC Mannitol on compression

    Benefits of an optimal tabletability DC Mannitol on compression setting parameters

    Newsfeeds - 29/05/2024 -
    This case study presented during the 14th PBP World Meeting discusses the challenges associated with tablet production, particularly focusing on the issue of tablet capping and the need for high …
    round-tablets-on-yellow-background-3683057

    PEARLITOL® 200 GT Mannitol: Harnessing the potential of higher active ingredient content for smaller, more convenient tablets

    Newsfeeds - 20/02/2024 -
    The article discusses the development and optimization of PEARLITOL® 200 GT, a new pure beta mannitol grade for direct compression in tablet manufacturing. Mannitol is commonly used as an excipient …
    Effect of geometrical features on the capping behavior of biconvex tablets

    Effect of geometrical features on the capping behavior of biconvex tablets

    Papers - 03/09/2023 - by Vincent Mazel, Cléo Garcia, Pierre Tchoreloff
    Capping is a prevalent issue in the pharmaceutical tablet manufacturing process, influenced by both process and formulation parameters. This study systematically examined the impact of the geometrical features of biconvex …
    ME-092-EN-A_Tableting_Rheology_and_Quality_by_D.original

    Tableting rheology and quality by design

    White Papers - 18/01/2023 -
    Quality by Design (QbD) in tablet development can be challenging, due to the multiple competing technological aims, such as flow, compactability, lubrication and drug release. Tablets are complex and, whether …
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    The assessment of the capping tendency of the tablet during the pharmaceutical tabletting using finite element analysis in computational modelling tools

    Papers - 29/11/2022 - by Halahakoon Hmaj
    The pharmaceutical powder compression cycle involves multiple stages, each associated with intricate mechanisms such as particle rearrangement, densification, inter-particle interaction, friction, elastic and plastic deformation, and particle fragmentation. A comprehensive …
    On the complexity of predicting tablet capping

    On the complexity of predicting tablet capping

    Papers - 23/06/2022 - by J. Meynard, F. Amado-Becker, P. Tchoreloff, V. Mazel
    Anticipating tablet defects, particularly capping, during the pharmaceutical manufacturing process poses a considerable challenge. The existing literature presents various parameters for predicting capping, yet a consensus has not been reached. …
    Impact of unloading kinematics on the occurrence of capping during the production of pharmaceutical tablets

    Impact of unloading kinematics on the occurrence of capping during the production of pharmaceutical tablets

    Papers - 10/06/2022 - by J. Meynard, F. Amado-Becker, P. Tchoreloff, V. Mazel
    Capping, a common defect in pharmaceutical tablet manufacturing, has been associated with a decrease in the unloading speed during the manufacturing cycle, as indicated by several studies. Building on this …
    capping

    Effect of precompresion on capping tendency

    Bulletins - 06/04/2022 - by Sixtine Caquant
    Compaction simulators are a key technology allowing scientists to develop formulations and troubleshoot tablet defects. It means that formulation scientists or tech transfer engineers can assess the influence of process …
    tablet_defect.original

    Troubleshooting tablet defects in no-time

    White Papers - 12/10/2021 - by Bruno Leclercq
    There are numerous tablet defects: chipping, picking & sticking, cracking, lamination & capping to name a few.Lamination & capping often occur during scale-up and are main issues in our industry. …
    ribblets.original

    A fundamental step in your tablet development

    Bulletins - 01/09/2021 - by Adrien Pelloux
    Formulation development and technical transfer from lab to production can be challenging and requires a deep knowledge of your formulation. The integrated and intuitive data analysis features drive formulators and …
    Enabling the direct compression of metformin hydrochloride through QESD crystallization

    Enabling the direct compression of metformin hydrochloride through QESD crystallization

    Papers - 01/06/2021 - by Jerome Hansen, Peter Kleinebudde
    Metformin hydrochloride, employed in treating type 2 diabetes, exhibits notable challenges with poor flowability and agglomeration during storage, making direct compression into tablets a hitherto unsuccessful endeavor. A previous study …
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    Role of precompression in the mitigation of capping: a case study

    Papers - 01/10/2020 - by Vincent Mazel, Pierre Tchoreloff
    Capping, a significant issue in pharmaceutical tablet manufacturing, involves the detachment of one of the tablet's convex portions during ejection from the press or after relaxation. Currently, solutions to this …
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    Quantification of tablet sensitivity to a stress concentration: Generalization of Hiestand's approach and link with the microstructure

    Papers - 01/06/2020 - by B. Croquelois, J. Girardot, J.B. Kopp, P. Tchoreloff, V. Mazel
    Sensitivity to a stress concentration is important for the development of pharmaceutical tablets as it is related to defects like capping. The Brittle Fracture Index (BFI) was introduced by Hiestand …
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    Quantification of tablet sensitivity to a stress concentration: generalization of Hiestand's approach and link with the microstructure

    Papers - 01/06/2020 - by B. Croquelois, J. Girardot, J.B. Kopp, P. Tchoreloff, V. Mazel
    The sensitivity to stress concentration is a crucial factor in the development of pharmaceutical tablets, given its association with defects such as capping. Hiestand et al. introduced the Brittle Fracture …
    Influence of the unloading conditions on capping and lamination: Study on a compaction simulator

    Influence of the unloading conditions on capping and lamination: Study on a compaction simulator

    Papers - 15/08/2019 - by Vincent Mazel, Léo Desbois, Pierre Tchoreloff
    Capping and lamination, traditional challenges in industrial processes, can pose difficulties when scaling up solid dosage forms. Previous research has demonstrated that altering the unloading conditions, such as triaxial decompression …
    Etude de la compression pharmaceutique à l'aide d'une approche de mécanique des milieux continus

    Etude de la compression pharmaceutique à l'aide d'une approche de mécanique des milieux continus

    Papers - 20/12/2018 - by Vincent Mazel
    L'ensemble de mon parcours de recherche, entamé il y a plus de 10 ans, a été centré sur la science des matériaux. J'ai eu la chance de travailler dans des …
    Early detection of capping risk in pharmaceutical compacts

    Early detection of capping risk in pharmaceutical compacts

    Papers - 01/12/2018 - by Xiaochi Xu, Chaitanya Krishna Prasad Vallabh, Stephen W. Hoag, Vivek S. Dave, Cetin Cetinkaya
    The detection of capping, a prevalent mechanical defect in tablet manufacturing, is crucial for pharmaceutical industry processes. This study introduces a non-destructive contact ultrasonic method for identifying capping risk in …
    Lamination of biconvex tablets: numerical and experimental study

    Lamination of biconvex tablets: numerical and experimental study

    Papers - 05/05/2018 - by Vincent Mazel, Harona Diarra, Jérôme Malvestio, Pierre Tchoreloff
    Capping and lamination are prevalent issues in the pharmaceutical tablet manufacturing process. Although these problems are often addressed collectively, they represent distinct failure patterns in tablets and consequently involve different …
    Shear strength of pharmaceutical tablets: Theoretical considerations, evaluation and relation with the capping tendency of biconvex tablets

    Shear strength of pharmaceutical tablets: Theoretical considerations, evaluation and relation with the capping tendency of biconvex tablets

    Papers - 30/10/2017 - by V. Mazel, H. Diarra, V. Busignies, P. Tchoreloff
    Capping poses a significant challenge in pharmaceutical powder compression, particularly in the context of biconvex tablets. Some studies suggest that capping results from a shear failure. Therefore, investigating shear strength …
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    Unravelling capping issues using STYL’One dwell time or punch speed

    Papers - 01/01/2016 - by Susana Nieto Bobadilla, Bruno Leclercq, Thierry Menard, Regis Cazes, Thomas Vermeulin
    Capping is a prevalent issue encountered in tablet formulation and industrial production, with various factors attributed to its origin, such as air entrapment, compression speed, viscoelastic recovery, and stress and …