Close search
Scientific papers

Scientific papers

Favorite Articles

    Tags

    Categories

    Authors

    483 results
    Date
    no-image

    Quantification of tablet sensitivity to a stress concentration: generalization of Hiestand's approach and link with the microstructure

    Papers - 01/06/2020 - by B. Croquelois, J. Girardot, J.B. Kopp, P. Tchoreloff, V. Mazel
    The sensitivity to stress concentration is a crucial factor in the development of pharmaceutical tablets, given its association with defects such as capping. Hiestand et al. introduced the Brittle Fracture …
    Functionality of disintegrants with different mechanisms after roll compaction

    Functionality of disintegrants with different mechanisms after roll compaction

    Papers - 01/06/2020 - by Sabrina Berkenkemper, Hannah Lou Keizer, Marc Lindenberg, Anikó Szepes, Peter Kleinebudde
    The objective of this study was to assess the functionality of two disintegrants, namely crospovidone and croscarmellose sodium, in tablet formulations processed through roll compaction followed by tableting. The investigation …
    A facile and novel approach to manufacture paclitaxel-loaded proliposome tablet formulations of micro or nano vesicles for nebulization

    A facile and novel approach to manufacture paclitaxel-loaded proliposome tablet formulations of micro or nano vesicles for nebulization

    Papers - 01/06/2020 - by Iftikhar Khan, Katie Lau, Ruba Bnyan, Chahinez Houacine, Matthew Roberts, Abdullah Isreb, Abdelbary Elhissi, Sakib Yousaf
    Objective: This study aimed to develop innovative paclitaxel-loaded proliposome tablet formulations for pulmonary drug delivery. Methodology: Various proliposome powder formulations (F1–F27) were prepared, utilizing Lactose monohydrate (LMH), Microcrystalline cellulose (MCC), …
    Delta-mannitol to enable continuous twin-screw granulation of a highly dosed, poorly compactable formulation

    Delta-mannitol to enable continuous twin-screw granulation of a highly dosed, poorly compactable formulation

    Papers - 01/06/2020 - by V. Vanhoorne, R. Almey, T. De Beer, C. Vervaet
    In this present study, we explored whether the moisture-mediated polymorphic transition from δ- to β-mannitol observed during twin screw granulation (TSG) could occur in formulations with a high drug load. …
    Investigation of critical factors affecting mechanical characteristics of press-coated tablets using a compaction simulator

    Investigation of critical factors affecting mechanical characteristics of press-coated tablets using a compaction simulator

    Papers - 30/05/2020 - by Thi-Tram Nguyen, Hye-Ryeong Park, Cheol-Hee Cho, Kyu-Mok Hwang, Eun-Seok Park
    Press-coated tablets have become essential in chronotherapeutic drug delivery, yet limited knowledge exists about their mechanical characteristics. This study systematically explores the effects of crucial factors on tablet structure, layer …
    Roller compaction scale-up made simple: an approximate analytical solution to Johanson's rolling theory

    Roller compaction scale-up made simple: an approximate analytical solution to Johanson's rolling theory

    Papers - 01/05/2020 - by Ricardo Sousa, Pedro Cardoso Valente, Mostaf Nakach, Lionel Bardet, Marie Wacquet, Noel Midoux, Jean-Rene Authelin
    We derive an approximate analytical solution to Johanson's rolling theory, demonstrating that the solution produces a single dimensionless parameter that remains invariant during process scale-up or equipment transfer. This parameter …
    Partial tablet coating by 3D printing

    Partial tablet coating by 3D printing

    Papers - 01/05/2020 - by Eleni Tsintavi, Dimitrios M. Rekkas, Ruggero Bettini
    Over the past decade, there has been a growing interest in 3D printing (3DP) technology within the pharmaceutical field, addressing various challenges such as on-demand manufacturing at the point of …
    Influence of formulation parameters on redispersibility of naproxen nanoparticles from granules produced in a fluidized bed process

    Influence of formulation parameters on redispersibility of naproxen nanoparticles from granules produced in a fluidized bed process

    Papers - 16/04/2020 - by Martin Wewers, Stefan Czyz, Jan Henrik Finke, Edgar John, Bernard Van Eerdenbrugh, Michael Juhnke, Heike Bunjes, Arno Kwade
    Reducing the particle size of active pharmaceutical ingredients is an efficient strategy for addressing challenges related to poor aqueous solubility. To enhance stability and patient convenience, nanosuspensions are often converted …
    Compression of vectors for small interfering RNAs delivery: toward oral administration of siRNA lipoplexes in tablet forms

    Compression of vectors for small interfering RNAs delivery: toward oral administration of siRNA lipoplexes in tablet forms

    Papers - 06/04/2020 - by Virginie Busignies, Danielle Campiol Arruda, Christine Charrueau, Marcela Coelho Silva Ribeiro, Anne-Marie Lachagès, Angelo Malachias, Stéphanie Finet, Asad Ur Rehman, Pascal Bigey, Pierre Tchoreloff, Virginie Escriou
    Presently, the majority of nonviral nucleic acid vectors are formulated as colloidal suspensions primarily administered parenterally. This formulation and administration method impose significant constraints, such as vector size limitations and …
    Structure-properties relationship in the evaluation of alginic acid functionality for tableting

    Structure-properties relationship in the evaluation of alginic acid functionality for tableting

    Papers - 01/04/2020 - by Rihab Benabbas, Noelia M. Sanchez-Ballester, Bernard Bataille, Laurent Leclercq, Tahmer Sharkawi, Ian Soulairol
    This study aims to explore the interrelation between the structural, molecular, and particulate attributes of alginic acid and its functional traits in direct compression, encompassing tabletability, compressibility, elasticity, deformation mechanism, …
    Switch of tablet manufacturing from high shear granulation to twin-screw granulation using quality by design approach

    Switch of tablet manufacturing from high shear granulation to twin-screw granulation using quality by design approach

    Papers - 01/04/2020 - by Yuta Miyazaki, Vincent Lenhart, Peter Kleinebudde
    The objective of this study was to transition from a high shear granulation (HSG) process to a twin-screw granulation (TSG) process while ensuring comparable dissolution profiles. Ibuprofen (IBP) was utilized …
    Insights on the role of excipients and tablet matrix porosity on aspirin stability

    Insights on the role of excipients and tablet matrix porosity on aspirin stability

    Papers - 01/04/2020 - by Natalia Veronica, Celine Valeria Liew, Paul Wan Sia Heng
    The interaction between excipients and moisture can significantly impact product stability. This study aimed to investigate the influence of incorporating excipients with varying moisture interactions into formulations containing a moisture-sensitive …
    Scaling tableting processes from compaction simulator to rotary presses— mind the sub-processes

    Scaling tableting processes from compaction simulator to rotary presses— mind the sub-processes

    Papers - 31/03/2020 - by Isabell Wünsch, Irene Friesen, Daniel Puckhaber, Thomas Schlegel, Jan Henrik Finke
    Compaction simulators are widely employed in tablet formulation and process development due to their flexibility, low material consumption, and advanced instrumentation, offering a comprehensive understanding of the compaction process. However, …
    crushed tablets

    An in-line, high sensitivity, non-contact sensor for the detection of initiation of sticking

    Papers - 01/03/2020 - by James Thomas, Antonios Zavaliangos
    Objective This paper explores the development and evaluation of a laser sensor designed to identify the onset of sticking during tablet manufacturing. Methodology The device operates on the fundamental principle …
    Effect of particle size on powder compaction and tablet strength using limestone

    Effect of particle size on powder compaction and tablet strength using limestone

    Papers - 01/03/2020 - by Ramon Cabiscol, Hao Shi, Isabell Wünsch, Vanessa Magnanimo, Jan Henrik Finke, Stefan Luding, Arno Kwade
    The compaction of powders at high loads poses a challenge due to the simultaneous occurrence of particle rearrangement, compression, and breakage. Although tableting is a pivotal process in pharmaceutical technology, …
    no-image

    Integrating QbD tools for flexible scale-up batch size selection for solid dosage forms

    Papers - 01/03/2020 - by Naseem A. Charoo, Ziyaur Rahman
    The current definition of the pilot scale batch size for solid oral dosage forms, set by major regulatory agencies as one-tenth of full production or 100,000 units, whichever is larger, …
    Paclitaxel-loaded micro or nano transfersome formulation into novel tablets for pulmonary drug delivery via nebulization

    Paclitaxel-loaded micro or nano transfersome formulation into novel tablets for pulmonary drug delivery via nebulization

    Papers - 15/02/2020 - by Iftikhar Khan, Maria Apostolou, Ruba Bnyan, Chahinez Houacine, Abdelbary Elhissi, Sakib S Yousaf
    A straightforward approach was employed to develop innovative paclitaxel (PTX) loaded protransfersome tablet formulations intended for pulmonary drug delivery. Leveraging the expansive surface area of the pulmonary system, the goal …
    Systematic approach to elucidate compaction behavior of acyclovir using a compaction simulator

    Systematic approach to elucidate compaction behavior of acyclovir using a compaction simulator

    Papers - 01/02/2020 - by Cheol-Hee Cho, Ju-Young Kim, Eun-Seok Park
    In this study, various methodologies were employed using a compaction simulator to explore the compaction behavior of acyclovir, a model compound with unidentified characteristics. Multiple indicators were utilized to assess …
    Along the process chain to probiotic tablets: evaluation of mechanical impacts on microbial viability

    Along the process chain to probiotic tablets: evaluation of mechanical impacts on microbial viability

    Papers - 15/01/2020 - by Karl Vorländer, Ingo Kampen, Jan Henrik Finke, Arno Kwade
    At present, probiotics are predominantly utilized in liquid or semi-solid functionalized foods, resulting in a rapid decline in cell viability. Considering the escalating issue of antibiotic resistance, probiotics hold promise …
    no-image

    Investigation on the effect of roller compaction on paracetamol

    Papers - 02/01/2020 - by Justin Yong Soon Tay, Qi En Han, Celine Valeria Liew, Paul Wan Sia Heng
    Roller compaction stands out as a widely employed dry granulation method, often linked with a decline in tabletability. This study delves into the impact of roller compaction on a model …