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    Use of roller compaction and fines recycling process in the preparation of erlotinib hydrochloride tablets

    Use of roller compaction and fines recycling process in the preparation of erlotinib hydrochloride tablets

    Papers - 02/02/2019 - by Kyu-Mok Hwang, Sang-Yeop Kim, Thi-Tram Nguyen, Cheol-Hee Cho, Eun-Seok Park
    This study aims to enhance the manufacturing process of a generic immediate-release tablet containing erlotinib hydrochloride by introducing a fines recycling step during roller compaction. The initial powder mixture faced …
    Manufacturing of multi-drug formulations with customised dose by solvent impregnation of mesoporous silica tablets

    Manufacturing of multi-drug formulations with customised dose by solvent impregnation of mesoporous silica tablets

    Papers - 01/01/2019 - by Marek Šoltys, Sarah Akhlasová, Aleš Zadražil, Pavel Kovačík, František Štěpánek
    The production of personalized medicines, where specific combinations of active pharmaceutical ingredients (APIs) and their doses within a tablet are adjusted to individual patient needs, necessitates novel manufacturing approaches compared …
    Effect of friction between powder and tooling on the die-wall pressure evolution during tableting: Experimental and numerical results for flat and concave punches

    Effect of friction between powder and tooling on the die-wall pressure evolution during tableting: Experimental and numerical results for flat and concave punches

    Papers - 01/01/2019 - by V. Mazel, H. Diarra, P. Tchoreloff
    The final properties of tablets are predominantly determined during the compaction process by the development of stresses applied to the powder. Any parameter related to the process or product that …
    Are natural lubricants suitable for texturized mannitol oral dispersible tablets?

    Are natural lubricants suitable for texturized mannitol oral dispersible tablets?

    Papers - 01/01/2019 - by Olaf Häusler, Nicolas Tarlier, Philippe Lefevre
    Mannitol possesses physical and chemical inertness, along with several advantageous organoleptic properties, making it the preferred excipient for formulating nutraceutical tablets. The [starch + mannitol] compound PEARLITOL® Flash serves as …
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    Itraconazole-HPMCAS amorphous spray dried dispersions: composition and process factors impacting performance

    Papers - 01/01/2019 - by Moshe Avraham Honick
    Despite their potential to enhance the oral bioavailability of poorly water-soluble drugs, spray-dried dispersions (SDDs) present formulation challenges due to their specific properties. This dissertation aimed to clarify the composition …
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    QbD approach formulation design for metformin HCI and evaluations

    Papers - 01/01/2019 - by Omar Hourani
    This study aimed to formulate Metformin HCI 500 mg tablets using the Direct Compression (DC) method, selecting appropriate excipients, and evaluating the formulation outcomes. In order to achieve an optimized …
    Etude de la compression pharmaceutique à l'aide d'une approche de mécanique des milieux continus

    Etude de la compression pharmaceutique à l'aide d'une approche de mécanique des milieux continus

    Papers - 20/12/2018 - by Vincent Mazel
    L'ensemble de mon parcours de recherche, entamé il y a plus de 10 ans, a été centré sur la science des matériaux. J'ai eu la chance de travailler dans des …
    Modeling of disintegration and dissolution behavior of mefenamic acid formulation using numeric solution of Noyes-Whitney equation with cellular automata on microtomographic and algorithmically generated surfaces

    Modeling of disintegration and dissolution behavior of mefenamic acid formulation using numeric solution of Noyes-Whitney equation with cellular automata on microtomographic and algorithmically generated surfaces

    Papers - 03/12/2018 - by Reiji Yokoyama, Go Kimura, Christian Schlepütz, Jörg Huwyler, Maxim Puchkov
    Manufacturing parameters can significantly influence the dissolution and disintegration of solid dosage forms. In alignment with Process Analytical Technology (PAT) and Quality by Design (QbD) approaches, computer-based technologies offer the …
    Towards a better understanding of dry binder functionality

    Towards a better understanding of dry binder functionality

    Papers - 01/12/2018 - by Oscar-Rupert Arndt, Peter Kleinebudde
    Gaining a profound understanding of the binding behavior and functionality of different types of dry binders is crucial, as these play a pivotal role in ensuring the desirable properties of …
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    Impact of different dry and wet granulation techniques on granule and tablet properties: a comparative study

    Papers - 01/12/2018 - by Oscar-Rupert Arndt, Roberto Baggio, Anna Kira Adam, Julia Harting, Erica Franceschinis, Peter Kleinebudde
    A comparative analysis was conducted on four granulation techniques to assess their impact on granule properties and tablet tensile strength. A common formulation was selected for processing through wet and …
    Early detection of capping risk in pharmaceutical compacts

    Early detection of capping risk in pharmaceutical compacts

    Papers - 01/12/2018 - by Xiaochi Xu, Chaitanya Krishna Prasad Vallabh, Stephen W. Hoag, Vivek S. Dave, Cetin Cetinkaya
    The detection of capping, a prevalent mechanical defect in tablet manufacturing, is crucial for pharmaceutical industry processes. This study introduces a non-destructive contact ultrasonic method for identifying capping risk in …
    Simplified end-to-end continuous manufacturing by feeding API suspensions in twin-screw wet granulation

    Simplified end-to-end continuous manufacturing by feeding API suspensions in twin-screw wet granulation

    Papers - 01/12/2018 - by Adrian Schmidt, Hans de Waard, Klaus-Peter Moll, Peter Kleinebudde, Markus Krumme
    This study aimed to explore the integration of continuous manufacturing for drug substance and drug product in an end-to-end continuous manufacturing process. The key step in this integrated approach involved …
    Influence of spray nozzle aperture during high shear wet granulation on granule properties and its compression attributes

    Influence of spray nozzle aperture during high shear wet granulation on granule properties and its compression attributes

    Papers - 01/12/2018 - by Natalia Veronica, Hui Ping Goh, Christina Yong Xin Kang, Celine Valeria Liew, Paul Wan Sia Heng
    The distribution of granulating liquid is acknowledged to influence the high shear wet granulation process, but the impact of spray nozzle attributes remains unclear. While a spray nozzle can achieve …
    How relevant is ribbon homogeneity in roll compaction/dry granulation and can it be influenced?

    How relevant is ribbon homogeneity in roll compaction/dry granulation and can it be influenced?

    Papers - 01/12/2018 - by Raphael Wiedey, Rok Šibanc, Annika Wilms, Peter Kleinebudde
    The conventional belief suggests that achieving a uniform distribution of the solid fraction in ribbons is advantageous during roll compaction/dry granulation. Many efforts have been made to enhance this uniformity …
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    Tricalcium citrate – a new brittle tableting excipient for direct compression and dry granulation with enormous hardness yield

    Papers - 03/10/2018 - by Veronika Hagelstein, Markus Gerhart, Karl G. Wagner
    Objective: This study is dedicated to characterizing tricalcium citrate (TCC) as a tableting excipient, examining its suitability for both direct compression (DC) and dry granulation (DG). Significance: Tablets crafted from …
    Characterization of mechanical property distributions on tablet surfaces

    Characterization of mechanical property distributions on tablet surfaces

    Papers - 02/10/2018 - by Ramon Cabiscol, Jan Finke, Harald Zetzener, Arno Kwade
    Powder densification during uniaxial compaction involves concurrent processes influenced by stress gradients within the packing, as well as frictional and adhesive forces between the powder and the die walls. This …
    Tablet vs mini-tablets

    Glibenclamide mini-tablets with an enhanced pharmacokinetic and pharmacodynamic performance

    Papers - 01/10/2018 - by Hesham M. Tawfeek, Matthew Roberts, Mohamed A. El Hamd, Ahmed A. H. Abdellatif, Mahmoud A. Younis
    In an effort to reduce the dosage, anticipated side effects, and production costs of glibenclamide (GLC), a potent oral hypoglycemic drug, the study aimed to enhance dissolution and, consequently, oral …
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    Evaluation of the super disintegrant functionnalities of alginic acid and calcium alginate for the design of orodispersible mini tablets

    Papers - 01/10/2018 - by Ian Soulairol, Noelia M. Sanchez-Ballester, Adrien Aubert, Nicolas Tarlier, Bernard Bataille, Françoise Quignard, Tahmer Sharkawi
    This study investigates the impact of various synthesis methods and drying conditions on the production of sodium alginate-derived xerogels, which exhibit notable disintegrant functionalities. Xerogels containing alginic acid (AA), calcium …
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    Evaluation of the performance of an external lubrication system implemented in a compaction simulator

    Papers - 01/09/2018 - by Cedrine de Backere, Valerie Vanhoorne, Chris Vervaet
    The application of internal lubrication is commonly linked to a reduction in tensile strengths and an increase in disintegration times. In contrast, external lubrication involves spraying the lubricant onto tablet …
    Gluing pills technology: A novel route to multilayer tablet manufacturing

    Gluing pills technology: A novel route to multilayer tablet manufacturing

    Papers - 01/09/2018 - by Valjon Demiri, Sandra Stranzinger, Paul Rinner, Michael Piller, Stephan Sacher, Josef Lingitz, Johannes Khinast, Sharareh Salar-Behzadi
    Controlling layer weight, preventing delamination, and minimizing cross-contamination pose significant challenges in the production of compacted multilayer tablets (MLT). This study introduces a novel manufacturing approach for MLT called Gluing …