Effect of binder type and lubrication method on the binder efficacy for direct compression

Sept. 25, 2021, midnight - by Cedrine de Backere , Thomas De Beer , Chris Vervaet , Valérie Vanhoorne

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1. Introduction: The incorporation of a binder into a direct compression formulation aims to enhance tablet tensile strength and mitigate tablet defects. The internal blending of magnesium stearate (MgSt) is commonly associated with a reduction in tensile strengths and an increase in disintegration times. This study aims to alleviate these adverse effects through external lubrication. 2. Objective: The objective is to investigate the impact of different binders and lubrication methods on ejection force, tablet tensile strength, and disintegration time in tablets produced through direct compression. This involves establishing a connection between binder properties and tablet tensile strength and disintegration behavior, employing partial least square (PLS) analysis.

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