Scientific papers
The viability of probiotic microorganisms is critical for their health benefits and must be carefully preserved throughout the production of final dosage forms, such as tablets. This includes processes like drying and tableting. Saccharomyces cerevisiae is spray-dried with protective additives identified in a previous study, which also explored the impact of formulation on tableting performance. However, the effect of multiple compression cycles, typical in rotary tablet presses using pre- and main compression, has not yet been thoroughly examined.
To address this, tablets were compressed up to five times. The results reveal that, when considering both tablet strength and microorganism survival, the use of pre- and main compression does not significantly influence outcomes. This supports the applicability of findings from single-compression phase studies to broader tablet manufacturing scenarios. Additionally, the data reinforce the previously identified mechanism of microorganism inactivation during tableting, attributed to porosity reduction. The study demonstrates that the method of achieving this reduction—whether through increased compression stress or additional compression cycles—is inconsequential.
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