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Investigation of the tableting process in continuous production: influence of feeding and extended dwell time during compression on dependent process variables and tablet properties

Papers - 01/01/2014 - by Elisabeth Peeters
Despite the daily production of large quantities of tablets, many of the established processes and formulations have evolved through (suboptimal) trial-and-error experiments, leading to the perception that the pharmaceutical powder …
Impact of the lubricant mixing time on the compactibility and disintegration time for mannitol compacts

Impact of the lubricant mixing time on the compactibility and disintegration time for mannitol compacts

Papers - 01/01/2014 - by N Tarlier, B Bataille, G Baylac, P Lefèvre, C Popescu, T Sharkawi
The aim of this study was to assess how varying the mixing conditions of Magnesium stearate (MgSt) affects the compaction behavior and disintegration time of diverse formulations based on mannitol. …
Characterization of functionalized calcium carbonate as a new pharmaceutical excipient

Characterization of functionalized calcium carbonate as a new pharmaceutical excipient

Papers - 01/01/2014 - by Tanja Stirnimann, Jörg Huwyler, Kurt E. Hersberger
Excipients play a crucial role in developing advanced, reliable formulations with enhanced patient compliance, optimizing plasma concentrations, and minimizing side effects. Modern excipients are expected to exhibit multifunctionality to enable …
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Tablet-in-cup drug delivery device drug release modification by tablet geometry

Papers - 01/01/2014 - by Leonie Hattler, Rainer Alles, Jörg Huwyler, Maxim Puchkov
AIMS: • Designing TIC devices • Exploring the potential of TIC design for modifying drug release • Simulating TIC drug release in silico
Role of the elasticity of pharmaceutical materials on the interfacial mechanical strength of bilayer tablets

Role of the elasticity of pharmaceutical materials on the interfacial mechanical strength of bilayer tablets

Papers - 30/11/2013 - by Virginie Busignies, Vincent Mazel, Harona Diarra, Pierre Tchoreloff
The impact of the elasticity of various pharmaceutical materials on the interfacial adhesion in bilayer tablets was explored. The elastic properties of five pharmaceutical products were assessed based on their …
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On the links between elastic constants and effective elastic behavior of pharmaceutical compacts: importance of poisson's ratio and use of bulk modulus

Papers - 01/11/2013 - by Vincent Mazel, Virginie Busignies, Harona Diarra, Pierre Tchoreloff
The elastic properties of pharmaceutical powders and compacts play a crucial role in comprehending the intricate phenomena occurring during and after the tableting process. Elastic recovery following compression is known …
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Production of extended release mini-tablets using directly compressible grades of HPMC

Papers - 01/11/2013 - by Faiezah A. A. Mohamed, Matthew Roberts, Linda Seton, James L. Ford, Marina Levina, Ali R. Rajabi-Siahboomi
Background: Hypromellose (HPMC) has been utilized previously to regulate drug release in mini-tablets. However, due to suboptimal flow characteristics, the production of mini-tablets with elevated HPMC levels presents a challenge. …
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Mechanistic insights into the scale‐up of the roller compaction process: a practical and dimensionless approach

Papers - 01/10/2013 - by Jasmine M. Rowe, John R. Crison, Thomas J. Carragher, Nipa Vatsaraj, Ryan J. Mccann, Faranak Nikfar
While the roller compaction process may seem straightforward, attempts to quantitatively model the process have been challenging due to the complex behavior of materials in the feeding and compaction zones. …
FEM simulation of the die compaction of pharmaceutical products: Influence of visco-elastic phenomena and comparison with experiments

FEM simulation of the die compaction of pharmaceutical products: Influence of visco-elastic phenomena and comparison with experiments

Papers - 10/09/2013 - by Harona Diarra, Vincent Mazel, Virginie Busignies, Pierre Tchoreloff
This study explores the impact of incorporating viscoelastic behavior in finite element method (FEM) modeling during die compaction of pharmaceutical products and its potential to enhance the correlation between experimental …
Image analysis quantification of sticking and picking events of pharmaceutical powders compressed on a rotary tablet press simulator

Image analysis quantification of sticking and picking events of pharmaceutical powders compressed on a rotary tablet press simulator

Papers - 01/09/2013 - by Germinal Mollereau, Vincent Mazel, Virginie Busignies, Pierre Tchoreloff, Fabrice Mouveaux, Philippe Rivière
Objective This study aimed to develop a quantification method utilizing image analysis to characterize sticking during pharmaceutical tableting. The research focused on exploring the relationship between image analysis features and …
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The influence of HPMC concentration on release of theophylline or hydrocortisone from extended release mini-tablets

Papers - 01/08/2013 - by Faiezah A. A. Mohamed, Matthew Roberts, Linda Seton, James L. Ford, Marina Levina, Ali R. Rajabi-Siahboomi
Context: Mini-tablets, compact dosage forms typically 2–3 mm in diameter, offer potential advantages for paediatric drug delivery. Extended-release (ER) oral dosage forms aim to provide controlled drug release for prolonged …
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Bonding mechanisms involved in the roller compaction of an amorphous food material

Papers - 01/07/2013 - by James Osborne
Roller compaction, a dry agglomeration process employing high stresses, binds powder particles together to form an agglomerate known as a ribbon. The prevailing bonding mechanism depends on the material's compressibility, …
Processing challenges with solid dosage formulations containing vitamin E TPGS

Processing challenges with solid dosage formulations containing vitamin E TPGS

Papers - 01/02/2013 - by Preetanshu Pandey, Patrick D. Sinko, Dilbir S. Bindra, Rhye Hamey, Shruti Gour, Chandra Vema-Varapu
This study aims to explore the challenges associated with incorporating Vitamin E TPGS (d-α tocopheryl polyethylene glycol 1000 succinate) into solid pharmaceutical dosage forms. Employing a wet granulation process involving …
A combined experimental and modeling approach to study the effects of high-shear wet granulation process parameters on granule characteristics

A combined experimental and modeling approach to study the effects of high-shear wet granulation process parameters on granule characteristics

Papers - 01/02/2013 - by Preetanshu Pandey, Jing Tao, Anwesha Chaudhury, Rohit Ramachandran, Julia Z. Gao, Dilbir S. Bindra
The current study aims to investigate the impact of high-shear wet granulation process parameters on granule characteristics through a combination of experimental and modeling approaches. A full factorial design of …
Prediction of the compressibility of complex mixtures of pharmaceutical powders

Prediction of the compressibility of complex mixtures of pharmaceutical powders

Papers - 05/10/2012 - by V. Busignies, V. Mazel, H. Diarra, P. Tchoreloff
The development of predictive models for the pharmaceutical compaction process holds significant importance, not only in the formulation stage but also within the framework of Quality by Design (QbD) development. …
Roller compaction process development and scale up using Johanson model calibrated with instrumented roll data

Roller compaction process development and scale up using Johanson model calibrated with instrumented roll data

Papers - 01/10/2012 - by Vishwas V. Nesarikar, Chandrakant Patel, William Early, Nipa Vatsaraj, Omar Sprockel, Robert Jerzweski
Roller compaction serves as a dry granulation process transforming powder blends into freely flowing agglomerates. When expanding or transferring the roller compaction process, maintaining comparable ribbon densities across scales becomes …
Tablet and mini tablets

Development and evaluation of sustained-release Compritol ® 888 ATO matrix mini-tablets

Papers - 01/09/2012 - by Matthew Roberts, Daniele Vellucci, Shabbir Mostafa, Cedric Miolane, Delphine Marchaud
Context: Sustained-release mini-tablets hold promise for pediatric drug delivery and as multiparticulate dosage forms. Objective: Assess the feasibility of developing lipophilic matrix mini-tablets and examine the impact of Compritol® 888 …
Measurements of elastic moduli of pharmaceutical compacts: A new methodology using double compaction on a compaction simulator

Measurements of elastic moduli of pharmaceutical compacts: A new methodology using double compaction on a compaction simulator

Papers - 01/06/2012 - by Vincent Mazel, Virginie Busignies, Harona Diarra, Pierre Tchoreloff
The compaction process heavily relies on the elastic properties of pharmaceutical powders. Young's modulus (E) and Poisson's ratio (v) are key parameters representing the elastic behavior. However, as the powder …
Instrumented roll technology for the design space development of roller compaction process

Instrumented roll technology for the design space development of roller compaction process

Papers - 01/04/2012 - by Vishwas V. Nesarikar, Nipa Vatsaraj, Chandrakant Patel, William Early, Preetanshu Pandey, Omar Sprockel, Zhihui Gao, Robert Jerzewski, Ronald Miller, Michael Levin
The Alexanderwerk® WP120 roller compactor incorporates instrumented roll technology, which was successfully developed and applied for measuring normal stress on the ribbon throughout the compaction process. The study investigated the …
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Investigation into the impact of sub-populations of agglomerates on the particle size distribution and flow properties of conventional microcrystalline cellulose grades

Papers - 01/10/2011 - by John F. Gamble, Wing-Sin Chiu, Mike Tobyn
Microcrystalline cellulose (MCC) stands out as a highly adaptable tablet filler binder, widely employed in both granulation and direct compression processes. Previous research has revealed that MCC particle populations consist …