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    Role of precompression in the mitigation of capping: a case study

    Papers - 01/10/2020 - by Vincent Mazel, Pierre Tchoreloff
    Capping, a significant issue in pharmaceutical tablet manufacturing, involves the detachment of one of the tablet's convex portions during ejection from the press or after relaxation. Currently, solutions to this …
    Evaluation of an external lubrication system implemented in a compaction simulator

    Evaluation of an external lubrication system implemented in a compaction simulator

    Papers - 25/09/2020 - by Cedrine de Backere, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    The internal blending of magnesium stearate is often linked to a reduction in tensile strengths and extended disintegration and dissolution times. Consequently, external lubrication has gained attention in the pharmaceutical …
    Applicability of impulse excitation technique as a tool to characterize the elastic properties of pharmaceutical tablets: Experimental and numerical study

    Applicability of impulse excitation technique as a tool to characterize the elastic properties of pharmaceutical tablets: Experimental and numerical study

    Papers - 16/09/2020 - by Vincent Mazel, Pierre Tchoreloff
    Elastic properties play a crucial role in tablet development, particularly in formulating the composition and defining process parameters. This article introduces impulse excitation as an innovative, rapid, and cost-effective technology …
    The effects of spray drying, HPMCAS grade, and compression speed on the compaction properties of itraconazole-HPMCAS spray dried dispersions

    The effects of spray drying, HPMCAS grade, and compression speed on the compaction properties of itraconazole-HPMCAS spray dried dispersions

    Papers - 16/09/2020 - by Moshe Honick, Sharmila Das, Stephen W. Hoag, Francis X. Muller, Alaadin Alayoubi, Xin Feng, Ahmed Zidan, Muhammad Ashraf, James E. Polli
    Spray-dried dispersions (SDDs) hold considerable potential in enhancing the oral bioavailability of drugs with limited water solubility. Nevertheless, SDDs often exhibit material attributes, such as small particle size, low bulk …
    A study on the formulation of plant matrix tablets from coarse botanical materials using cinnamon bark and areca nut as the model botanical materials

    A study on the formulation of plant matrix tablets from coarse botanical materials using cinnamon bark and areca nut as the model botanical materials

    Papers - 30/08/2020 - by National University of Singapore Singapore, Natalia Veronica, Xiu Hui Ang, Shing Ming Ooi, Celine Valeria Liew, Paul Wan Sia Heng
    There is considerable interest in formulating tablets with botanical materials, primarily due to their compactness and ease of administration. However, the tableting of coarsely milled botanical materials presents challenges owing …
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    Influence of formulation parameters on tablet surface properties and film coating adhesion

    Papers - 01/08/2020 - by Martin Wewers, Gernot Warnke, Jan Henrik Finke
    Film coatings on tablets are commonly used to confer specific properties, such as achieving particular drug release profiles. The surface characteristics of tablet cores play a crucial role in the …
    Polyglycerol esters of fatty acids as safe and stable matrix forming tableting excipients: a structure-function analysis

    Polyglycerol esters of fatty acids as safe and stable matrix forming tableting excipients: a structure-function analysis

    Papers - 01/08/2020 - by Sharareh Salar Behzadi, Julia Karrer, Valon Demiri, Brenda Barrios, Carolina Corzo, Claudia Meindl, Dirk Lochmann, Sebastian Reyer
    This study introduces an innovative approach to developing stable extended-release matrix tablets through direct compaction. The chosen molecules belong to polyglycerol esters of fatty acids (PGFAs), a category of lipid-based …
    Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation process via wet and dry binder addition

    Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation process via wet and dry binder addition

    Papers - 30/07/2020 - by L. Vandevivere, P. Denduyver, C. Portier, O. Häusler, T. De Beer, C. Vervaet, V. Vanhoorne
    The impact of various binders on the quality of granules produced through continuous twin-screw wet granulation was investigated. Anhydrous dicalcium phosphate served as a poorly soluble filler, and binders were …
    Characterization and modeling of the viscoelasticity of pharmaceutical tablets

    Characterization and modeling of the viscoelasticity of pharmaceutical tablets

    Papers - 28/07/2020 - by Léo Desbois, Pierre Tchoreloff, Vincent Mazel
    The variation in compaction properties of powders with compaction speed, known as strain rate sensitivity (SRS), is a common occurrence in the pharmaceutical tablet manufacturing process. However, various phenomena, such …
    Impact of structural relaxation on mechanical properties of amorphous polymers

    Impact of structural relaxation on mechanical properties of amorphous polymers

    Papers - 20/07/2020 - by Karsten Flügel, Robert Hennig, Markus Thommes
    Fusion-based techniques, such as hot-melt extrusion, are commonly employed for the preparation of amorphous solid dispersions. However, the amorphous glass obtained through these methods is not in configurational equilibrium, leading …
    Compression behaviour of granules produced via twin-screw melt granulation: effect of initial particle size on granulation efficiency

    Compression behaviour of granules produced via twin-screw melt granulation: effect of initial particle size on granulation efficiency

    Papers - 17/07/2020 - by Kristina E. Steffens, Karl G. Wagner
    This investigation delves into the influence of the initial particle size on the tabletability and deformation behavior (specifically plasticity) of granules produced through twin-screw melt granulation (TSMG). As model substances, …
    Biopharmaceutical implications of excipient variability on drug dissolution from immediate release products

    Biopharmaceutical implications of excipient variability on drug dissolution from immediate release products

    Papers - 16/07/2020 - by P. Zarmpi, T. Flanagan, E. Meehan, J. Mann, J. Østergaard, N. Fotaki
    Examining the influence of excipient variability on oral product performance from a biopharmaceutical perspective could be advantageous and facilitate the integration of excipients into Quality by Design (QbD) approaches. The …
    Development of alginate esters as novel multifunctional excipients for direct compression

    Development of alginate esters as novel multifunctional excipients for direct compression

    Papers - 15/07/2020 - by Noelia M. Sanchez-Ballester, Bernard Bataille, Rihab Benabbas, Bruno Alonso, Ian Soulairol
    Evaluations have been conducted on methyl ester derivatives of alginic acid as potential multifunctional excipients for pharmaceutical direct compression. The utilization of alginic acid as an excipient in tablet formulation …
    Robustness of controlled release tablets based on a cross-linked pregelatinized potato starch matrix

    Robustness of controlled release tablets based on a cross-linked pregelatinized potato starch matrix

    Papers - 01/07/2020 - by D. Elgaied-Lamouchi, N. Descamps, P. Lefèvre, A. R. Mackin-Mohamour, C. Neut, F. Siepmann, Juergen Siepmann, S. Muschert
    The objective of this research was to assess the viability of utilizing cross-linked pregelatinized potato starch (marketed as PREGEFLO ® PI10) as a matrix former for controlled release tablets. Various …
    Influence of the porosity of cushioning excipients on the compaction of coated multi-particulates

    Influence of the porosity of cushioning excipients on the compaction of coated multi-particulates

    Papers - 01/07/2020 - by Ramy N. Elsergany, Lai Wah Chan, Paul Wan Sia Heng
    Compacting tablets in a multiple unit-pellet system (MUPS) presents significant challenges due to potential damage to the functional polymer coat and the risk of pellet segregation during the tableting process. …
    High-molecular-weight hypromellose from three different suppliers: effects of compression speed, tableting equipment, and moisture on the compaction

    High-molecular-weight hypromellose from three different suppliers: effects of compression speed, tableting equipment, and moisture on the compaction

    Papers - 01/07/2020 - by Peter Grdešič, Amrit Paudel, Ilija German Ilić
    The increasing significance of higher tableting speeds in the pharmaceutical industry prompts a need for comprehensive studies on the mechanical properties of hypromellose. Surprisingly, there is a lack of recent …
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    Cushioning pellets based on microcrystalline cellulose – Crospovidone blends for MUPS tableting

    Papers - 26/06/2020 - by Ramy N. Elsergany, Lai Wah Chan, Paul Wan Sia Heng
    Compaction of multiple-unit pellet system (MUPS) tablets has been extensively reported to be potentially challenging. Thus, there is a need for non-segregating cushioning agents to mitigate the deleterious effect of …
    Cushioning pellets based on microcrystalline cellulose – Crospovidone blends for MUPS tableting

    Cushioning pellets based on microcrystalline cellulose – Crospovidone blends for MUPS tableting

    Papers - 26/06/2020 - by Ramy N. Elsergany, Lai Wah Chan, Paul Wan Sia Heng
    Compacting tablets within a multiple-unit pellet system (MUPS) has been widely acknowledged as potentially challenging. Consequently, there is a growing demand for non-segregating cushioning agents to alleviate the adverse effects …
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    Recent progress in roll compaction process development for pharmaceutical solid dosage form manufacture

    Papers - 11/06/2020 - by Ariel R. Muliadi, Alamelu Banda, Chen Mao
    Over the past decade, roll compaction technologies have seen significant advancements, becoming increasingly favored by formulation scientists for granulation purposes. This chapter provides an overview of recent developments in pharmaceutical …
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    Quantification of tablet sensitivity to a stress concentration: Generalization of Hiestand's approach and link with the microstructure

    Papers - 01/06/2020 - by B. Croquelois, J. Girardot, J.B. Kopp, P. Tchoreloff, V. Mazel
    Sensitivity to a stress concentration is important for the development of pharmaceutical tablets as it is related to defects like capping. The Brittle Fracture Index (BFI) was introduced by Hiestand …