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    Biopharma 4.0 – Spearheading Digital Transformation In The Biopharmaceutical Industry - image

    Biopharma 4.0 – Spearheading digital transformation in the biopharmaceutical industry

    Newsfeeds - 03/12/2024 -
    Biopharma 4.0, a sector-specific evolution of Industry 4.0, focuses on the full digital integration of biopharmaceutical manufacturing processes to enhance efficiency, agility, and quality. According to Chris Demers, Ph.D., of …
    Partnership with knowledge gain - on both sides

    Partnership with knowledge gain – on both sides

    Newsfeeds - 26/11/2024 -
    The partnership between KORSCH, MEDELPHARM, and the Institute of Particle Technology (iPAT) at the Technical University of Braunschweig focuses on advancing tableting technologies and understanding powder behavior through collaborative research. …
    KORSCH XT 600 Pharma Networking

    KORSCH bringing to PMEC India tabletting solutions from R&D to high-speed production

    Newsfeeds - 25/11/2024 -
    KORSCH Highlights Innovation at PMEC India 2024Berlin-based tablet compression leader KORSCH AG will showcase its cutting-edge technologies at PMEC India 2024, held at the India Expo Centre, Greater Noida, under …
    Digitalization

    This Takeda official thinks pharma 4.0 won't be optional much longer

    Newsfeeds - 20/11/2024 -
    Gunter Baumgartner, Takeda's global head of engineering, discusses the necessity of digital transformation in the pharmaceutical industry, emphasizing that Pharma 4.0 is evolving from a competitive advantage to an essential …
    Pharma 4.0 Che Manager - image

    Pharma's Digital Transformation

    Newsfeeds - 20/11/2024 -
    Industry experts from ISPE's Pharma 4.0 guide core team, including Michelangelo Canzoneri, Josef Trapl, Wolfgang Winter, Christian Woelbeling, and Thomas Zimmer, discuss the challenges and opportunities of the digital Pharma …
    In-line porosity and hardness monitoring of tablets by means of optical coherence tomography

    In-line porosity and hardness monitoring of tablets by means of optical coherence tomography

    Newsfeeds - 20/11/2024 -
    In-line monitoring of critical quality attributes (CQAs) during the tableting process is a crucial step toward implementing a real-time release strategy. These CQAs include tablet mass, API content, dissolution, hardness, …
    Timeline of US and EU regulations impacting pediatric therapies

    Combining patient centricity and commercial viability in pediatric product development

    Newsfeeds - 14/11/2024 -
    In pediatric drug formulation, achieving patient adherence and acceptance is crucial due to children’s rapid development and unique pharmacokinetic profiles. Pediatric formulations face specific challenges, including complex regulations, formulation demands, …
    2-single-layer-tablets

    Identify your lead solid form early to reduce timelines and downstream costs

    Newsfeeds - 08/11/2024 -
    This article, according to a webinar by Lonza Small Molecules, argues that prioritizing identification of the optimal solid form for a drug during the early phases of development can significantly …
    KORSCH Innovation Center

    Win-win for industry and research

    Newsfeeds - 04/11/2024 -
    Bruno Leclercq, Global Coordinator of the KORSCH INNOVATION CENTERs and MEDELPHARM Science Lab, emphasizes the importance of cooperation with universities and research institutions. The centers serve as hubs for formulation …
    Scaling for Commercialization - Considerations for large-scale API Production

    Scaling for commercialization: considerations for large-scale API production

    Newsfeeds - 04/11/2024 -
    Scaling up from clinical development to larger batch sizes involves numerous challenges and complexities that must be addressed to ensure successful outcomes. Key factors such as risk mitigation, production scalability, …
    Increasing the bioavailability of oncology drugs with amorphous solid dosage formulations - Image

    Increasing the bioavailability of oncology drugs with amorphous solid dosage formulations

    Newsfeeds - 04/11/2024 -
    Developing oral formulations for oncology drugs poses challenges, particularly due to their pH-dependent solubility. This is especially critical for tyrosine kinase inhibitors (TKIs), which face inconsistent bioavailability affected by factors …
    Photo AAPS 2024 - James on KORSCH booth

    MEDELPHARM's participation at AAPS PharmSci 360 2024: Innovations in tablet formulation

    Newsfeeds - 30/10/2024 - by Gabrielle Dupont
    At the recent AAPS PharmSci 360, held from October 20th-23rd, 2024, in Salt Lake City, MEDELPHARM showcased its latest advancements in tablet formulation technology alongside KORSCH America. This collaboration featured …
    Optimal formulation development

    Optimal formulation development

    Newsfeeds - 24/10/2024 -
    Formulation development is a crucial aspect of the drug development process, involving activities such as developability assessment, buffer optimization, dosage form studies, and compatibility testing. Early investment in formulation development …
    tablets nutra 2

    eBook: Navigating the Nutraceuticals Landscape in 2024

    Newsfeeds - 23/10/2024 -
    The nutraceutical ingredients market is undergoing rapid growth and transformation, fueled by rising consumer awareness around health and wellness. It is projected to grow from $87.76 billion in 2024 to …
    Weight uniformity in tablet manufacturing - the critical role in tablet efficacy

    Weight uniformity in tablet manufacturing - the critical role in tablet efficacy

    Newsfeeds - 22/10/2024 -
    The article discusses the critical importance of tablet weight uniformity in the tablet manufacturing process, emphasizing its role in ensuring that each tablet consistently delivers the intended dosage of key …
    Meeting the challenges of rising API complexity

    Meeting the challenge of rising API complexity: Lonza IP- and reaxys AI-enabled route design technology

    Newsfeeds - 17/10/2024 -
    The complexity of small molecule active pharmaceutical ingredients (APIs) is increasing, resulting in longer synthesis processes that pose challenges for innovators aiming for timely clinical readiness. Extended synthetic pathways complicate …
    Challenges to data integrity in the pharma lab

    Challenges to data integrity in the pharma lab

    Newsfeeds - 15/10/2024 -
    To prioritize data integrity in pharmaceutical R&D, companies must implement strong data practices throughout the process, ensuring the fidelity and confidentiality of all data types, including raw data, metadata, and …
    Powder_Explosion_Red_iStock-525212190

    Pharmaceutical granulation: enhancing drug manufacturing efficiency

    Newsfeeds - 11/10/2024 -
    Granulation is a vital process in pharmaceutical manufacturing, where fine powder particles are combined into larger, free-flowing granules. This process is crucial for enhancing the physical properties of drug formulations, …
    white-tablets-close-up

    Drug product formulation & process development: the must-have skills at a glance

    Newsfeeds - 10/10/2024 -
    Drug product formulation and process development are critical yet often understated aspects of developing new drugs. Professionals in this field possess multidisciplinary skills, including organic chemistry, analytical development, solid-state characterization, …
    Image flexible modelling of the dissolution performance of directly compressed tablets

    Flexible modelling of the dissolution performance of directly compressed tablets

    Newsfeeds - 08/10/2024 -
    This study proposes a compartmental disintegration and dissolution model to predict and evaluate the dissolution behavior of directly compressed tablets. The model consists of three compartments (Bound, Disintegrated, and Dissolved) …
    high-angle-view-white-medical-pills

    New dosage forms come with new challenges: a guide to overcoming analysis and quality control issues in R&D and manufacture

    Newsfeeds - 08/10/2024 -
    Pharmaceutical researchers and manufacturers are motivated to create new dosage forms that enhance drug delivery effectiveness while also improving patient compliance and overall experience.Today's patients prioritize products that offer exceptional …
    assorted-pharmaceutical-medicine-pills-tablets-capsules-high-quality-photo

    From technology selection to final drug product: material sparing approaches for asd development

    Newsfeeds - 04/10/2024 -
    Compounds with low solubility and poor bioavailability present ongoing challenges in pharmaceutical development. This webinar explores Lonza's ‘right first time’ strategy, which employs material-efficient and time-saving techniques to accelerate the …
    MEDELPHARM_CPHI_Nano_Demonstration

    MEDELPHARM and Armor Pharma collaborate for innovative formulation development at CPHI 2024

    Newsfeeds - 03/10/2024 -
    MEDELPHARM is excited to announce its participation at CPHI 2024 in Milan, exhibiting in collaboration with Armor Pharma, a leading manufacturer of pharmaceutical excipients. Together, they will present live demonstrations …
    Evolution of the die-wall pressure during the compression of biconvex tablets: experimental results and comparison with FEM simulation

    Trends in solid dosage forms and their challenges for R&D and manufacture

    Newsfeeds - 02/10/2024 -
    Innovation is essential for the pharmaceutical industry, with a focus not only on new active ingredients but also on advancements in drug delivery and targeting systems. These improvements enhance drug …
    Image - Pharmtech development of mini-tablet and multi-unit pellet systems

    Mini tabs dosage accuracy: are you gambling with patient safety

    Newsfeeds - 01/10/2024 -
    The pharmaceutical industry is experiencing a notable increase in demand for mini-tablets, often referred to as micro-tablets or mini-tabs. These have become a preferred choice among healthcare professionals due to …
    Powder-heap-white-6

    Powder analysis: the next level

    Newsfeeds - 20/09/2024 -
    In pharmaceutical manufacturing, optimizing the characteristics of powders—such as flowability, solubility, consistency, purity, and stability—is crucial for the successful formulation of oral dosage forms. However, powder characterization is a complex …
    Compaction simulator & scientist

    Compaction simulation with KORSCH and MEDELPHARM

    Newsfeeds - 18/09/2024 -
    Compaction simulation technology plays a critical role in developing pharmaceutical dosage forms for high-speed tablet production. MEDELPHARM's STYL’One compaction simulators optimize the blend of active pharmaceutical ingredients (APIs) and excipients, …
    White-Powder-Petri-Dishes-2

    Spray drying for a sticky API (low glass transition temperature)

    Newsfeeds - 16/09/2024 -
    It is widely recognized that 40% of New Chemical Entities (NCEs) in the pharmaceutical industry exhibit poor solubility, resulting in inadequate bioavailability. Spray drying has emerged as a promising particle …
    tablet white

    A recipe for success: mastering tableting requires understanding ingredient attributes

    Newsfeeds - 12/09/2024 -
    The author discusses the importance of understanding ingredient attributes in the process of tablet manufacturing. It emphasizes that consistently producing high-quality tablets requires more than just creating a successful small-scale …
    Image Solid Dosage Form manufacture via twin screw extrusion (coperion)

    Solid dosage form manufacturing via twin screw extrusion

    Newsfeeds - 11/09/2024 -
    The text describes the use of Twin Screw Extrusion (TSE) in pharmaceutical solid dosage form manufacturing, particularly focusing on the advantages of TSE for granulation and hot melt extrusion (HME). …
    Orally-disintegrating-tablets-offer-range-of-patient-benefits

    Adapting to an ageing world: formulation strategies to boost patient compliance

    Newsfeeds - 11/09/2024 -
    The text discusses the challenges of medication compliance in older adults and how the pharmaceutical industry can address these through advanced drug formulations. With the global aging population rapidly increasing, …
    Comprehensive Review of Modern Techniques of Granulation in Pharmaceutical Solid Dosage Forms

    Comprehensive review of modern techniques of granulation in pharmaceutical solid dosage forms

    Newsfeeds - 29/08/2024 -
    The review provides an extensive overview of granulation techniques in pharmaceutical manufacturing, comparing traditional and modern methods. It details dry granulation techniques such as slugging, roller compaction, and pneumatic dry …
    Mannitol-coated hydroxypropyl methylcellulose as an alternative directly compressible

    Mannitol-coated hydroxypropyl methylcellulose as an alternative directly compressible controlled release excipient

    Newsfeeds - 28/08/2024 -
    One of the most common forms of controlled release technology for oral drug delivery involves dispersing an active ingredient in a hydrophilic matrix-forming polymer like hydroxypropyl methylcellulose (HPMC), which is …
    AI in drug delivery

    Advances in artificial intelligence in drug delivery and development

    Newsfeeds - 20/08/2024 -
    AI is transforming healthcare, particularly in drug delivery and development. This review explores AI's current and future roles in the pharmaceutical industry, focusing on smart drug delivery networks, sensors, drug …
    Powder_Explosion_Red_iStock-525212190

    Excipients used for solid dosage: innovations and challenges

    Newsfeeds - 14/08/2024 -
    *Excipients Used for Solid Dosage: Innovations and ChallengesSolid dosage forms are preferred in pharmaceuticals due to their ease of administration, accuracy, and cost-effectiveness. However, their effectiveness depends not just on …
    Image effect of glidant on tabletting behavior

    The effect of glidant on the tabletting behavior of common pharmaceutical excipients

    Newsfeeds - 09/08/2024 -
    The article on Pharma Excipients discusses the impact of glidants on the tabletting process in pharmaceutical manufacturing. Glidants are substances added to improve the flow properties of powders during tablet …
    Trends in amorphous solid dispersion drug products approved by the US food and drug administration

    Trends in amorphous solid dispersion drug products approved by the U.S. Food and Drug Administration between 2012 and 2023

    Newsfeeds - 08/08/2024 -
    Between 2012 and 2023, the U.S. FDA approved 48 drug products (DPs) containing amorphous solid dispersions (ASDs), involving 36 unique amorphous drugs across 10 therapeutic categories, predominantly antiviral and antineoplastic …
    Image webinar Pharmaceutical Spray Drying

    Pharmaceutical spray drying: sustainable commercial best practices

    Newsfeeds - 05/08/2024 -
    Spray drying is a crucial process in the pharmaceutical industry for particle engineering and enhancing bioavailability. It is continuous and scalable, suitable for various stages from early assessments to large-scale …
    Image news From bench to batch strategies for scaling HPAPI production

    From bench to batch: strategies for scaling HPAPI production

    Newsfeeds - 29/07/2024 -
    Although the small molecule market has expanded at a CAGR of approximately 5.7% over the past decade, there is even greater interest and demand for HPAPIs, with growth rates around …
    Image Quality Imperatives In Oral Solid Dosage Manufacturing An Overview

    Quality imperatives in oral solid dosage manufacturing: an overview

    Newsfeeds - 26/07/2024 -
    The article "Quality Imperatives in Oral Solid Dosage Manufacturing: An Overview" discusses the critical aspects of ensuring quality in the manufacturing of oral solid dosage forms, such as tablets and …
    Image Oral solid dose pharmaceutical equipment auction announced for sept

    Oral solid dose pharmaceutical equipment auction announced for September 4-5, 2024

    Newsfeeds - 26/07/2024 -
    Source: Federal Equipment CompanyFederal Equipment’s latest auction is a multi-million dollar inventory reduction of high-quality pharmaceutical equipment. The auction takes place on September 4-5, 2024.REGISTER TO BIDVIEW CATALOGSale Information:Location: Cleveland, …
    Image Efficient Development Of Oral Drug Products Selecting A Dissolution Media

    Efficient development of drug products: selecting a dissolution media

    Newsfeeds - 24/07/2024 -
    The article discusses the importance of selecting the appropriate dissolution media in the efficient development of oral drug products. Dissolution testing is crucial for evaluating the release rate of a …
    Image Fluid Bed And Melt Granulation In Pharmaceutical Manufacturing

    Fluid bed and melt granulation in pharmaceutical manufacturing

    Newsfeeds - 22/07/2024 -
    The article provides an in-depth look at granulation in pharmaceutical manufacturing, emphasizing fluid bed and melt granulation techniques. Granulation is essential for creating high-quality pharmaceuticals due to its benefits in …
    Image data integrity

    Sharpening-pharmas-data-integrity-with-automation

    Newsfeeds - 16/07/2024 -
    The article discusses the increasing regulatory focus on data integrity in the pharmaceutical manufacturing industry, emphasizing the need for complete, consistent, and accurate data. This focus is due to the …
    Image early solid form screening

    Early solid form screening guide drug substance through drug product development

    Newsfeeds - 15/07/2024 -
    The article discusses the importance of early solid form screening in drug development. This process involves identifying the most stable and effective solid form of a drug substance early in …
    Image - article Adare pharma solutions

    Formulation considerations for pediatric populations: finding the right dosage form for better adherence

    Newsfeeds - 12/07/2024 -
    The text discusses the challenges and strategies for developing pediatric drug formulations to improve adherence and outcomes. It highlights the need for specialized technology platforms and expert partners to address …
    STYL'One Nano-DMU tabletting school-Sixtine

    Leveraging the STYL'One Nano compaction simulator for educational purposes

    Newsfeeds - 11/07/2024 -
    In the rapidly evolving field of pharmaceutical sciences, innovative tools and technologies are essential to advancing research and development. One such innovative instrument is the STYL'One Nano, offered by MEDELPHARM. …
    Tablet_TabInTab_5

    How To achieve different release profiles and select excipients for formulation development of modified release oral solid dosage forms

    Newsfeeds - 10/07/2024 -
    Modified release oral solid dosage forms (MROSD) are specialized formulations that enable drug release over a defined period or at specific GI tract locations, improving patient adherence and reducing side …
    Image 5 Steps To Improving Productivity In Pharma Manufacturing

    5 steps to improving productivity in pharma manufacturing

    Newsfeeds - 10/07/2024 -
    The text discusses the benefits of improved productivity in pharmaceutical manufacturing, such as increased output, greater product consistency, and decreased costs. It then outlines five strategies to enhance productivity:*Optimize and …
    STYL'One Evo scientist

    STYL’One Evo R&D – Scale-up and production support

    Newsfeeds - 10/07/2024 -
    The STYL’One Evo is a versatile, advanced R&D tablet press designed for use from early API characterization to production support. It is easy to use, clean, and maintain, featuring intuitive …
    standard tablets on blue background

    Ebook: Twin-screw extrusion for pharmaceutical applications

    Newsfeeds - 03/07/2024 -
    This compendium provides a comprehensive guide on how hot-melt extrusion (HME) can address common challenges in pharmaceutical development. It offers detailed guidance on all stages of the HME process, from …
    Image study - benefits of an optimal tabletability DC Mannitol on compression-resize

    Optimizing API load and minimizing tablet weight leveraging an innovative DC Mannitol

    Newsfeeds - 26/06/2024 -
    *INTRODUCTIONTablets with stability issues often utilize mannitol, a stable, water-soluble excipient. Direct compression is a preferred method for its simplicity and cost-effectiveness. However, directly compressible mannitol grades tend to cap …
    News Streamline early-stage development to reach the clinic faster - resize

    Streamline early-stage development to reach the clinic faster

    Newsfeeds - 25/06/2024 -
    Streamlining early-stage pharmaceutical development is essential for accelerating the transition to clinical trials. Early-stage development establishes a solid foundation for successful trials by defining a clear quality target product profile …
    Image article Digitalization enables sustainable pharma plant design

    Digitalization enables sustainable pharma plant design

    Newsfeeds - 24/06/2024 -
    The pharmaceutical sector is increasingly aware of the need for sustainable manufacturing, particularly given its high CO2 emissions, surpassing even the automotive sector. Major pharmaceutical companies are investing in eco-friendly …
    image - Real-world dosing solutions for patients

    Real world dosing solutions for patients

    Newsfeeds - 18/06/2024 -
    Discover how fast dissolve technology can offer dosing solutions for different patient populations.Zydis® ODT (orally dissolving tablet) is a distinctive, freeze-dried oral solid dosage form that dissolves almost immediately in …
    standard tablets on blue background

    Tablet manufacturing equipment is evolving

    Newsfeeds - 14/06/2024 -
    Tablet manufacturing equipment has evolved significantly due to the demands for business efficiency. Modern tablet presses are designed to make manufacturing faster, simpler, and more efficient, achieving higher tablet yields …
    Image MEDELPHARM STYL'One Nano for early-stage characterization

    STYL’One Nano R&D compaction simulator for early-stage material characterization and development

    Newsfeeds - 13/06/2024 -
    The MEDELPHARM STYL’One Nano is a compact and advanced compaction simulator designed for early-stage tablet formulation in research and development. It helps researchers address formulation challenges in tablet and oral …
    Image Recent Innovatioins and enhancements to pharmaceutial spray drying

    Recent innovations and enhancements to pharmaceutical spray drying

    Newsfeeds - 12/06/2024 -
    The text discusses the use of spray drying in the pharmaceutical industry for enhancing particle engineering and bioavailability, with a focus on Lonza's expertise and advancements.Key points include:*Spray Drying Process: …
    Image Effects of omitting titanium dioxide from the film coating of a pharmaceutical tablet

    Effects of omitting titanium dioxide from the film coating of a pharmaceutical tablet

    Newsfeeds - 11/06/2024 -
    This case study investigates the impact of removing titanium dioxide (TiO2) from the film coating of pharmaceutical tablets, in light of impending EU regulations banning TiO2 in pharmaceuticals. The study …
    Image improving active pharmaceutical ingredient formulation by hot melt extrusion

    Improving active pharmaceutical ingredient formulation by hot melt extrusion

    Newsfeeds - 10/06/2024 -
    This poster, presented at the PBP World Meeting 2024 in Vienna, explores the integration of AI and big data in pharmaceutical research, revolutionizing drug discovery. Despite advancements, challenges arise due …
    News Implemet a risk-based approach to safely manufacture HPAPIs (No)

    Implement a risk-based approach to safely manufacture HPAPIs

    Newsfeeds - 06/06/2024 -
    Highly potent active pharmaceutical ingredients (HPAPIs) are increasingly used for therapeutic purposes, especially in cancer treatment. As drug manufacturers ramp up HPAPI production, they face challenges in scaling these potent …
    image - a guide to understanding the importance of powder vapor containment

    A guide to understanding the importance of powder & vapor containment

    Newsfeeds - 06/06/2024 -
    The article by Dr. Bob Haugen and Dr. Allan Goodman addresses the importance of maintaining safe, non-toxic sterile work environments across various industries, including pharmaceuticals, first responders, and furniture companies. …
    white-medication-pill-on-blue-textile-3683079

    Webinar on demand - solid form screening of active pharmaceutical Ingredients

    Newsfeeds - 03/06/2024 -
    Solid form services serve as the crucial link between the development of drug substances and drug products for New Chemical Entities (NCEs). Early screening, selection, and isolation of the primary …
    Navigating grades and sources of materials in drug manufacturing

    Navigating grades and sources of materials in drug manufacturing

    Newsfeeds - 31/05/2024 -
    In drug manufacturing, understanding material quality—from raw materials to finished dosage forms (FDF)—is crucial. Complex global supply chains, inconsistent standards, and practical challenges in ensuring material suitability make sourcing and …
    5 best practices to ensure quality active pharmaceutical ingredients

    Five best practices to ensure quality active pharmaceutical ingredients

    Newsfeeds - 31/05/2024 -
    The global market for active pharmaceutical ingredients (API) was valued at approximately $173 billion in 2020 and is projected to reach $286 billion by 2027, driven by the demand for …
    Image study - benefits of an optimal tabletability DC Mannitol on compression

    Benefits of an optimal tabletability DC Mannitol on compression setting parameters

    Newsfeeds - 29/05/2024 -
    This case study presented during the 14th PBP World Meeting discusses the challenges associated with tablet production, particularly focusing on the issue of tablet capping and the need for high …
    KORSCH-XL4004-MFP

    KORSCH bringing world's most flexible tablet press to FCE Brazil expo

    Newsfeeds - 27/05/2024 -
    KORSCH AG, a leading tablet compression technology company, will showcase its advanced XL 400⁴ MFP Tablet Press at the FCE 2024 pharma industry expo in São Paulo, Brazil. TheXL 400⁴ …
    Tablet_Minitablet_vs_tablet_1

    Development of mini-tablet and multi-unit pellet systems (MUPs)

    Newsfeeds - 24/05/2024 -
    The text discusses the development and benefits of Mini-Tablet and Multi-Unit Pellet Systems (MUPS) in oral drug delivery. These advanced dosage forms offer controlled and sustained release profiles, achieved through …
    Image - Altascience issue 17 - Maximizing drug formulations

    Maximizing drug formulation for first-in-human trials

    Newsfeeds - 22/05/2024 -
    The primary goal of first-in-human (FIH) trials is to establish the initial dosage of a new drug, ensuring it is low enough to minimize safety and toxicity risks while allowing …
    Image - How to select the ideal HPAPI manufacturing partner

    How to select the ideal HPAPI manufacturing partner

    Newsfeeds - 21/05/2024 -
    The article discusses the challenges and strategies associated with safely manufacturing highly potent active pharmaceutical ingredients (HPAPIs). HPAPIs offer therapeutic benefits but pose risks to manufacturing personnel due to their …
    Merck - SEM showing highly stuctured surface area of Parteck M mannitol excipient

    Use of Mannitol as an excipient for solid drug formulation

    Newsfeeds - 16/05/2024 -
    The use of mannitol as an excipient in solid drug formulation offers several advantages, including its low hygroscopicity, inertness with respect to active pharmaceutical ingredients (APIs), and ability to produce …
    Image The Effect of Formulation Variables on the Manufacturability of Clopidogrel Tablets via Fluidized Hot-Melt Granulation

    The effect of formulation variables on the manufacturability of clopidogrel tablets via fluidized hot-melt granulation

    Newsfeeds - 16/05/2024 -
    This study investigates the challenges faced by solid pharmaceutical formulations containing class II active pharmaceutical ingredients (APIs) due to limited solubility, which affects their behavior in the body. Computational tools …
    Image - A solid dosage future

    A solid dosage future

    Newsfeeds - 14/05/2024 -
    About the documentary:"In the realm of pharmaceutical manufacturing, conventional drug formats like tablets, pills, and capsules retain their fundamental significance. Their widespread acceptance and familiarity among patients make them indispensable …
    pilules-bocal-verre

    Modified release formulations: extending drug commercial lifecycle

    Newsfeeds - 30/04/2024 -
    The text discusses the evolving landscape of drug release systems, emphasizing the shift from immediate release formulations to modified dosage forms. These modifications aim to enhance patient compliance, achieve therapeutic …
    pilules-blanches-tombent-bouteille

    Manufacturing equipment trends

    Newsfeeds - 30/04/2024 -
    The text provides an overview of pharmaceutical and biopharmaceutical manufacturing processes, emphasizing the need for flexibility, containment, and operating efficiency in equipment. It discusses trends in the industry such as …
    pilules-bocal-verre

    The benefits of using GenAI in drug discovery and preclinical development

    Newsfeeds - 26/04/2024 -
    The article discusses the potential benefits of utilizing generative artificial intelligence (GenAI) in drug discovery and preclinical development. It emphasizes how GenAI can reform the drug discovery process by creating …
    Image Trends in solid dosage forms - weight sorting

    Trends in solid dosage forms and their challenges for R&D and manufacture

    Newsfeeds - 24/04/2024 -
    CI Precision discusses the importance of innovation in the pharmaceutical industry, focusing on advancements in drug delivery and targeting systems. It highlights the significance of solid dosage forms beyond active …
    _DSC2084 copie

    MEDELPHARM bringing expertise in research and development at Compaction Simulation Forum in Dublin

    Newsfeeds - 22/04/2024 -
    MEDELPHARM, a leading name in pharmaceutical equipment and technology, is getting ready to participate at the upcoming Compaction Simulation Forum (CSF), scheduled to take place from June 4th to 6th …
    Image - Why are pharma companies reluctant cloud

    Why are pharmaceutical companies reluctant to adopt cloud technologies

    Newsfeeds - 22/04/2024 -
    The Cloud Industry Forum's 2023 report indicates that the majority of businesses across various sectors have adopted cloud technology, with 55% utilizing a hybrid approach and 42% embracing a cloud-first …
    Image - Choosing the optimal dosage form for your moleculex600

    Choosing the optimal dosage form for your molecule

    Newsfeeds - 22/04/2024 -
    There are many factors to consider when choosing the right oral dosage form for your active pharmaceutical ingredient (API) leading up to clinical trials, including:- Drug profile- Ease of formulation …
    pilules-bocal-verre

    Emerging trends and challenges for pharmaceutical production

    Newsfeeds - 15/04/2024 -
    The global pharmaceutical market, valued at around 1.25 trillion USD, is expected to grow steadily, with the United States leading in revenue generation. Despite the COVID-19 pandemic, pharmaceutical supply chains …
    Image Fabrication and Optimization of Directly Compressible Self-Emulsifying Tablets Containing Cannabis Extract Obtained from Supercritical Carbon Dioxide Extraction

    Fabrication and optimization of directly compressible self-emulsifying tablets containing cannabis extract obtained from supercritical carbon dioxide extraction

    Newsfeeds - 15/04/2024 -
    The text discusses the challenges of low bioavailability of Tetrahydrocannabinol (THC) and Cannabidiol (CBD) in orally administered cannabis extract due to first-pass metabolism. It explores the use of a self-emulsifying …
    Nano_on_table_transparent

    AustinPx invests in pharmaceutics and manufacturing capabilities to accelerate drug development

    Newsfeeds - 11/04/2024 -
    AustinPx, a prominent contract development and manufacturing organization (CDMO) focusing on enhancing the bioavailability of orally delivered small molecule drug candidates, has announced the acquisition of cutting-edge equipment to bolster …
    Image Hot-Melt extrusion - from theory to application in pharmaceutical formulation - where are we now

    Hot-melt extrusion: from theory to application in pharmaceutical formulation – where are we now?

    Newsfeeds - 10/04/2024 -
    Hot-melt extrusion (HME) stands as a widely acknowledged and robust technology, effectively enhancing the bioavailability of poorly soluble active pharmaceutical ingredients while offering an efficient continuous manufacturing process. The twin-screw …
    Image Right from the start Designing advanceable formulations and processes at phase 1

    Right from the start: designing advanceable formulations and processes at phase I

    Newsfeeds - 09/04/2024 -
    The text discusses the importance of designing drug formulations and processes that are advanceable from the early stages of development, emphasizing safety, efficacy, manufacturability, and commercial viability. It highlights the …
    Image Rapid And Material-Sparing Feasibility Screening For Hot Melt Extrusion

    Rapid and material-sparing feasibility screening for hot melt extrusion

    Newsfeeds - 05/04/2024 -
    Amorphous solid dispersions (ASD) present a solution for enhancing the bioavailability of crystalline APIs that are otherwise poorly soluble. Two primary methods for manufacturing ASDs are spray drying and hot …
    Illustration article Interphex

    KORSCH America highlights latest tableting technology during Interphex 2024

    Newsfeeds - 03/04/2024 -
    KORSCH America Inc., division of KORSCH AG., a leading name in the pharmaceutical equipment manufacturing industry, is preparing its participation at Interphex in New York. Scheduled from April 16th to …
    Image KORSCH X 5 Contract Pharma

    KORSCH to introduce advanced X 5 tablet press at INTERPHEX

    Newsfeeds - 02/04/2024 -
    KORSCH America, the U.S. subsidiary of KORSCH AG, will unveil its latest tablet press, the X 5, at INTERPHEX in New York City. This innovative single-sided rotary press offers increased …
    Image Impact testing as a new approach to determine mechanical strength of pharmaceutical tablets

    Impact testing as a new approach to determine mechanical strength of pharmaceutical tablets

    Newsfeeds - 02/04/2024 -
    The paper discusses shortcomings in traditional standardized testing methods for determining tablet strength in the pharmaceutical industry, particularly focusing on the tablet breaking force test and friability test. These methods …
    Image Continuous production KORSCH LB Bohle

    The role of continuous manufacturing in large-batch production

    Newsfeeds - 25/03/2024 -
    The text discusses the potential of Continuous Manufacturing as a production organization for pharmaceuticals, particularly in high-volume production. Dr. Robin Meier, Chief Scientific Officer at L.B. Bohle, provides insights into …
    Galenic laboratory Armor - video screen

    See the galenic laboratory at Armor Pharma

    Newsfeeds - 15/03/2024 -
    Since 2020, Armor Pharma has made significant investments in a cutting-edge galenic laboratory, enhancing their expertise as a leading pharmaceutical lactose provider.Check out the latest video showcasing Armor Pharma's State-of-the-art …
    ODT tab iStock-451630933

    Is my molecule suitable for an Orally Disintegrating Tablet

    Newsfeeds - 13/03/2024 -
    Orally Disintegrating Tablets (ODTs) are a favored option for patients, providing added advantages in terms of delivering and absorbing the active pharmaceutical ingredient (API) before reaching the stomach. Incorporating ODT …
    Image Excipient-based strategies to harness complex therapeutics

    Excipient-based strategies to harness complex therapeutics

    Newsfeeds - 12/03/2024 -
    The article discusses the challenges associated with small molecule drugs in pharmaceutical formulations, particularly focusing on their poor water solubility. It highlights that a significant percentage of marketed drugs and …
    image twin screw granulation process

    A QbD guided development of a Twin-Screw Granulation process

    Newsfeeds - 12/03/2024 -
    The text discusses dry granulation techniques in the pharmaceutical industry, focusing on roller compaction and slugging, highlighting their limitations such as inferior tablet strength and reduced yield due to fine …
    Bilayer tablet MEDELPHARM Vom hofe

    Bilayer tablet manufacturing - An overview

    Newsfeeds - 08/03/2024 -
    The text highlights the advantages and challenges of bilayer tablets in pharmaceutical formulations. Bilayer tablets offer controlled delivery of one or more active pharmaceutical ingredients (APIs) within a single tablet, …
    MEDELPHARM PBP World Meeting LinkedIn

    MEDELPHARM highlights innovative solutions at PBP World Meeting

    Newsfeeds - 06/03/2024 -
    MEDELPHARM, a leading provider of innovative solutions for pharmaceutical research and development, will be participating in the upcoming PBP World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology in Vienna from …
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    Best practices for preformulation in drug development

    Newsfeeds - 05/03/2024 -
    The text discusses the importance and methodologies of preformulation testing in drug development, which involves studying new drug compounds to gather essential information for formulating stable and biopharmaceutically suitable dosage …
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    MEGGLE highlights role of excipient properties in alcohol-induced dose dumping AIDD

    Newsfeeds - 01/03/2024 -
    The white paper from MEGGLE emphasizes the significance of excipients in addressing alcohol-induced dose dumping (AIDD) in modified-release tablet formulations. AIDD occurs when drugs prematurely release into the bloodstream due …
    Laboratory network - image - strategies to formulate poorly soluble api

    4 strategies to formulate poorly soluble APIs

    Newsfeeds - 01/03/2024 -
    The text discusses strategies employed by researchers and pharmaceutical scientists to address the challenge of poor solubility in APIs. It outlines four main techniques: lipid-based formulations, amorphous solid dispersions, nanotechnology, …
    Tablet_Multilayer_15_HD.original

    Retrospective analysis of the biopharmaceutics characteristics of solid oral Modified-Release drug products

    Newsfeeds - 20/02/2024 -
    This retrospective study, spanning from 2001 to 2021, examined submissions approved by the US Food and Drug Administration (FDA) for Modified Release (MR) orally administered drugs [Extended-Release (ER) and Delayed-Release …
    Yellow tablets iStock-1218616175

    Flexible granulation

    Newsfeeds - 20/02/2024 -
    The process of pharmaceutical granulation plays a pivotal role in producing solid dosage forms, directly influencing the efficacy, stability, and overall quality of the drug. Within pharmaceutical manufacturing, flexible granulation …
    round-tablets-on-yellow-background-3683057

    PEARLITOL® 200 GT Mannitol: Harnessing the potential of higher active ingredient content for smaller, more convenient tablets

    Newsfeeds - 20/02/2024 -
    The article discusses the development and optimization of PEARLITOL® 200 GT, a new pure beta mannitol grade for direct compression in tablet manufacturing. Mannitol is commonly used as an excipient …
    Granutools - Granupack Permeability

    Granutools introduces the GranuPack permeability

    Newsfeeds - 06/02/2024 -
    Granutools has introduced the GranuPack Permeability Unit, a revolutionary device for analyzing powder permeability in various packing conditions. Essential for industries like pharmaceuticals, food production, and additive manufacturing, the unit …
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    Modified-release formulation strategies

    Newsfeeds - 31/01/2024 -
    The increasing popularity of modified-release (MR) dosage forms is attributed to the numerous therapeutic advantages they provide for both drug developers and patients. Oral MR formulations are specifically designed to …
    KORSCH X 5

    New KORSCH X 5 advanced Single-Sided Tablet Press delivers major productivity gains

    Newsfeeds - 31/01/2024 -
    KORSCH AG has introduced the X 5 Tablet Press, an advanced single-sided rotary press that significantly enhances productivity in tablet manufacturing. Launched at Interpack 2023, the X 5 offers a …
    Image current trends and challenges influencing the oral solid dose market

    Current trends and challenges influencing the oral solid dose market

    Newsfeeds - 23/01/2024 -
    The article discusses current trends and challenges in the oral solid dose (OSD) market, focusing on the influence of patient-centric formulations and advancements in excipients. Key points include the importance …
    ThermoFisher - Solving for Solubility a scale-up strategy for spray-dried dispersions

    Solving for solubility: a scale-up strategy for spray dried dispersion

    Newsfeeds - 12/01/2024 -
    Webinar replay by ThermoFisherSpray drying provides a remedy for formulation obstacles in improving the bioavailability of poorly soluble APIs. While the procedure is thoroughly comprehended, achieving successful spray drying demands …
    cdmo industry INCOG

    3 key trends shaping the CDMO industry in 2024

    Newsfeeds - 12/01/2024 -
    The article discusses three key trends shaping the Contract Development and Manufacturing Organization (CDMO) industry in 2024 and beyond:* Transition Towards Customer-Driven Manufacturing (CdMO)- The biopharma industry is evolving, and …
    Image empowering the pharma workforce

    Empowering the pharma workforce

    Newsfeeds - 04/01/2024 -
    The pharmaceutical manufacturing industry is undergoing a significant transformation, facing challenges in workforce training, particularly due to rising costs and logistical issues. The emergence of generative AI (GenAI) is poised …
    Tablet_Multilayer_15_HD.original

    The effect of compression pressure on the first layer surface roughness and delamination of Metformin and Evogliptin bilayer and trilayer tablets

    Newsfeeds - 18/12/2023 -
    The study aimed to assess the delamination of convex-shaped tablets containing metformin HCl (MF) and evogliptin tartrate (EG) based on pre-compression and main compression pressures. Simultaneously, the study sought to …
    Lactalis Ingredients Pharma powder (from website)

    Development of pharmaceutical lactose by Lactalis Ingredients Pharma

    Newsfeeds - 12/12/2023 -
    Pharmaceutical grade lactose, used as binder or diluent, is a standard excipient for the formulation of Oral Solid Dose medicines. Versatile thanks to its various fabrication processes leading to different …
    illustration Exploring Best-Practice Manufacturing Strategies for Highly Potent Oral Solid Dosage Forms

    Exploring best-practice manufacturing strategies for highly potent oral solid dosage forms

    Newsfeeds - 23/11/2023 -
    Exploring key points for manufacturing Highly Potent Oral Solid Dosage Forms:*Challenges of Highly Potent Oral Solid Dose (HPOSD) Manufacturing:The increasing development and market presence of highly potent oral solid dose …
    Fig.-2-Tableting-study

    Tableting of liquid form active ingredient with high performance liquid carrier

    Newsfeeds - 07/11/2023 -
    The article discusses the use of FLORITE, a macro porous calcium silicate, as a practical alternative to liquid carriers for tableting formulations with liquid active ingredients.Fish oil was utilized as …
    reformulation by Biogrund

    The art of reformulation: tablet formulations redefined

    Newsfeeds - 06/11/2023 -
    The article discusses the significance of tablet reformulation in the pharmaceutical and dietary supplement industry. Reformulation is vital for improving efficacy, tolerability, and patent competitiveness. The process involves steps such …
    a qbd approach

    Technical considerations for developing oral solids

    Newsfeeds - 24/10/2023 -
    Part 1 of the series by Pfizer CentreOne focuses on technical considerations for developing oral solids. The article emphasizes the significance of thorough technical groundwork and understanding excipients during the …
    Medelpharm-Group of tablets

    How to achieve different release profiles and select excipients for formulation development of modified release oral solid dosage forms

    Newsfeeds - 24/10/2023 -
    The white paper by Societal CDMO takles the following key points:1 - Importance of modified release oral solid dosage forms in enabling prolonged or targeted drug delivery, leading to improved …
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    Characterizing drug substance properties early can optimize drug development formulation

    Newsfeeds - 23/10/2023 -
    This article examines the following key points: 1 - Early drug substance (DS) characterization is crucial as changes in the DS process can affect the drug product (DP), including purity, …
    KORSCH Magazine- high-volume tablet production

    KORSCH Magazine - high-volume tablet production

    Newsfeeds - 23/10/2023 -
    KORSCH AG takes a closer look at the developments, trends and future prospects around high-volume tablet production for pharma and nutraceutical applications. In addition, KORSCH presents their new X 5 …
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    KORSCH Magazine - research & development, our customers respond

    Newsfeeds - 27/06/2022 -
    KORSCH AG conducted revealing interviews with customers on this magazine focused on Research and Development. It provides a detailed insight into the processes and challenges involved in successful product development, …
    Skyepharma tab-in-tab

    Tab-in-tab: Skyepharma and Université de Bordeaux share collaborative thesis

    Newsfeeds - 16/05/2022 - by Léo Picart
    To read, directly on the Skyepharma website, an update on a collaborative thesis on “Mechanical resistance of pharmaceutical press coated tablets (tab-in-tab): characterization and link with material and process parameters”.This …
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    The expanding role of effervescent technology

    Newsfeeds - 08/04/2022 -
    This article explains the benefits and applications of effervescent technology in solid dosage forms from beverages to laundry detergent.
    Tablet_Multilayer_15_HD.original

    Exploring bilayer tablet manufacturing

    Newsfeeds - 01/12/2021 -
    Article published on Pharmaceutical Online that reviews selecting this specific dosage form, manufacturing challenges and how to overcome them, considerations for evaluating a CDMO, and the typical timeframe for scale-up.
    ME-S2-300-091

    What are advantages of external lubrication on a tablet press compared to folding lubrication into the blend?

    Newsfeeds - 07/10/2021 -
    Spotted across the web an efficient summary of the Pro's and Con's of adding MgSt directly into the product blend vs external lubrication.
    Orally-disintegrating-tablets-offer-range-of-patient-benefits

    Orally disintegrating tablets offer range of patient benefits: Roquette

    Newsfeeds - 24/08/2021 -
    A leader from the excipients firm discusses how ODTs appeal to seniors and patients on the go, and the formulation-related challenges with such tablets.
    first-impressions-tablet-shape-can-impact-2

    First impressions: tablet shape can impact patient acceptance

    Newsfeeds - 24/11/2020 -
    The article discusses the crucial role of tablet design in shaping consumer perception and acceptance, particularly in pharmaceutical, nutritional, and confectionary industries. It highlights the limitations of the flat faced …
    BRC_100_033 - L.B. Bohle

    Roller compaction: new trends, challenges and solutions

    Newsfeeds - 12/11/2020 -
    This article explains the 3 known technologies to develop tablets:- direct compression- wet granulation- dry granulation, with a focus on roller compaction, as it remains an effective solution for most …
    white-medication-pill-on-blue-textile-3683079.width-1200

    Are tablets still relevant?

    Newsfeeds - 17/07/2020 -
    CPI's Dave Berry explains the rising demand for tablets, and the trend towards continuous processing in the pharmaceutical industry. There is a need today for higher flexibility through modular physical …
    Orally-disintegrating-tablets-offer-range-of-patient-benefits

    List of excipients for direct compression

    Newsfeeds - 07/07/2020 -
    Pharma Excipients has released on their website a list of excipients that can be used for direct compression with the function/application and manufacturer. Binders, lubricants and disintegrants are an important …